Human beings can achieve a high level of motor performance that is still unmatched in robotic systems. These capabilities can be ascribed to two main enabling factors: (i) the physical proprieties of human musculoskeletal system, and (ii) the effectiveness of the control operated by the central nervous system. Regarding point (i), the introduction of compliant elements in the robotic structure can be regarded as an attempt to bridge the gap between the animal body and the robot one. Soft articulated robots aim at replicating the musculoskeletal characteristics of vertebrates. Yet, substantial advancements are still needed under a control point of view, to fully exploit the new possibilities provided by soft robotic bodies. This paper introduces a control framework that ensures natural movements in articulated soft robots, implementing specific functionalities of the human central nervous system, i.e., learning by repetition, after-effect on known and unknown trajectories, anticipatory behavior, its reactive re-planning, and state covariation in precise task execution. The control architecture we propose has a hierarchical structure composed of two levels. The low level deals with dynamic inversion and focuses on trajectory tracking problems. The high level manages the degree of freedom redundancy, and it allows to control the system through a reduced set of variables. The building blocks of this novel control architecture are well-rooted in the control theory, which can furnish an established vocabulary to describe the functional mechanisms underlying the motor control system. The proposed control architecture is validated through simulations and experiments on a bio-mimetic articulated soft robot.
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http://dx.doi.org/10.3389/frobt.2020.00117 | DOI Listing |
Eng Life Sci
January 2025
Analytical Development & Analytical Attribute Science in Biologics Bristol Myers Squibb Devens Massachusetts USA.
This study emphasizes the critical importance of closely monitoring and controlling the sialic acid content in therapeutic glycoproteins, including EPO, interferon-γ, Orencia, Enbrel, and others, as the level of sialylation directly impacts their pharmacokinetics (PK), immunogenicity, potency, and overall clinical performance due to its influence on protein clearance via hepatic asialoglycoprotein receptors (ASGPR). The ASGPR recognizes and binds to glycoproteins exposed to terminal galactose or N-acetylgalactosamine residues, leading to receptor-mediated endocytosis. Recent studies have demonstrated that sialylation of O-linked glycan plays a role in protecting against macrophage galactose lectin (MGL)-mediated clearance.
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January 2025
Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, 639 Zhizaoju Road, Shanghai, 200011, China.
The escalating hazards posed by bacterial infections underscore the imperative for pioneering advancements in next-generation antibacterial modalities and treatments. Present therapeutic methodologies are frequently impeded by the constraints of insufficient biofilm infiltration and the absence of precision in pathogen-specific targeting. In this current study, we have used chlorin e6 (Ce6), zeolitic imidazolate framework-8 (ZIF-8), polydopamine (PDA), and UBI peptide to formulate an innovative nanosystem meticulously engineered to confront bacterial infections and effectually dismantle biofilm architectures through the concerted mechanism of photodynamic therapy (PDT)/photothermal therapy (PTT) therapies, including in-depth research, especially for oral bacteria and oral biofilm.
View Article and Find Full Text PDFBMC Geriatr
January 2025
Department of Creative Product Design, Asia University, Taichung, Taiwan.
Alzheimer's disease (AD) is a complex, progressive, and irreversible neurodegenerative disorder marked by cognitive decline and memory loss. Early diagnosis is the most effective strategy to slow the disease's progression. Mild Cognitive Impairment (MCI) is frequently viewed as a crucial stage before the onset of AD, making it the ideal period for therapeutic intervention.
View Article and Find Full Text PDFSci Rep
January 2025
Hebei University of Architecture, Hebei, 075000, China.
Relying on the Beijing-Zhangjiakou high-speed railway Cao Mao Shan tunnel project, blasting vibration monitoring and sound wave testing experiments were carried out. The monitoring results show that the blasting vibration velocity corresponding to the initial support satisfies the Sadowski formula. The results of the sonic test show that with the increase of blasting times, the cumulative damage increases gradually, but the blasting damage increment shows a downward trend.
View Article and Find Full Text PDFSci Rep
January 2025
Institute of Architectural Engineering, Shanghai Zhongqiao Vocational and Technical University, Shanghai, 201514, China.
Prefabricated buildings have a series of advantages such as high efficiency, energy savings, and environmental protection, and are being strongly promoted by the Chinese government. However, due to the late start of prefabricated buildings in China, the installation process of prefabricated components is relatively complex, leading to difficulties in quality and safety control. A novel evaluation methodology integrating the technique for order preference by similarity to ideal solution (TOPSIS) with prospect theory and interval-valued Pythagorean fuzzy numbers (IVPFNs) is proposed.
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