AI Article Synopsis
- Parkinson's disease (PD) is a common neurodegenerative disorder with a notable genetic component, but the specific genes involved remain debated.
- This study aimed to evaluate the impact of two particular genetic polymorphisms on the risk of developing PD by comparing a group of patients with healthy controls.
- The results showed no significant association between the tested polymorphisms and PD, suggesting they are not major risk factors in the examined Greek population.
Article Abstract
Background: Parkinson's disease (PD) is the second commonest neurodegenerative disease. The genetic basis of PD is indisputable. Both and have been linked to PD, to some extent, but the exact role of those polymorphisms in PD remains controversial.
Objective: We assessed the role of and on PD risk.
Methods: We genotyped 358 patients with PD and 358 healthy controls for and . We also merged and meta-analyzed our data with data from previous studies, regarding these two polymorphisms and PD.
Results: No significant association with PD was revealed ( > 0.05), for either or , in any of the examined genetic model of inheritance. In addition, results from meta-analyses yield negative results.
Conclusions: Based on our analyses, it appears rather unlikely that or is among the major risk factors for PD, at least in Greek patients with PD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864159 | PMC |
| http://dx.doi.org/10.3390/jcm10030381 | DOI Listing |
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