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A New Variant Among Newcastle Disease Viruses Isolated in the Democratic Republic of the Congo in 2018 and 2019. | LitMetric

AI Article Synopsis

  • Newcastle disease (ND) is a serious and spreadable illness that impacts both poultry and wild birds around the world, necessitating a solid understanding of the ND virus (NDV) to effectively manage it.
  • In the Democratic Republic of the Congo (DRC), ND has been reported to affect poultry farming for years, but detailed genetic and virological data on the NDVs in the region have been lacking.
  • Recent research found new NDV variants in DRC that are closely related to existing vaccine strains, indicating that while current vaccines can control ND, further epidemiological studies are needed to improve disease management strategies.

Article Abstract

Newcastle disease (ND) is a highly transmissible and devastating disease that affects poultry and wild birds worldwide. Comprehensive knowledge regarding the characteristics and epidemiological factors of the ND virus (NDV) is critical for the control and prevention of ND. Effective vaccinations can prevent and control the spread of the NDV in poultry populations. For decades, the Democratic Republic of the Congo (DRC) has reported the impacts of ND on commercial and traditional poultry farming systems. The reports were preliminary clinical observations, and few cases were confirmed in the laboratory. However, data on the phylogenetic, genetic, and virological characteristics of NDVs circulating in the DRC are not available. In this study, the whole-genome sequences of three NDV isolates obtained using the next-generation sequencing method revealed two isolates that were a new variant of NDV, and one isolate that was clustered in the subgenotype VII.2. All DRC isolates were velogenic and were antigenically closely related to the vaccine strains. Our findings reveal that despite the circulation of the new variant, ND can be controlled in the DRC using the current vaccine. However, epidemiological studies should be conducted to elucidate the endemicity of the disease so that better control strategies can be implemented.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909526PMC
http://dx.doi.org/10.3390/v13020151DOI Listing

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