Postpartum hemorrhage: Could oxytocin be the cause? Results from a morbidity and mortality review to enhance quality, safety, and relevance of care.

Eur J Obstet Gynecol Reprod Biol

Department of Obstetrics and Gynaecology, René Dubos Hospital, Cergy-Pontoise, France; University Sorbonne Paris Cité, University Paris 13, Bobigny, France.

Published: March 2021

Introduction: A sudden postpartum hemorrhage (PPH) increase has been subjectively observed during summer 2018 in our level-3 maternity, despite following all official recommendations for PPH care. This observation led us to conduct a morbi-mortality review to understand morbidity increase reasons.

Methods: We conducted a first retrospective comparative cohort study from 2017 to 2018 to compare PPH rates. We conducted a second comparative study to determine the factors that may have led to an increase in PPH. One of the initial hypotheses of increased PPH was related to the weakness of oxytocin, exposed to high outside temperatures. The eight-day delivery records were analyzed, as follow: the high-frequency period of PPH (EXPOSED), the batch replacement of oxytocin (NON EXPOSED), and the same period of the previous year (1 YEAR BEFORE). We studied all known PPH risk factors: preconception, pregnancy, childbirth, and human, climatic, or material organizational factors in this maternity.

Results: 322 women were included: 111, 92, and 119 in the EXPOSED, NON EXPOSED, and 1 YEAR BEFORE groups, respectively. Sociodemographic data of the 3 groups were not different. The rate of PPH in the EXPOSED was significantly higher than that of NON EXPOSED, and 1 YEAR BEFORE: 20.7 %, 7.6 %, and 5.8 %, respectively (p = 0.0077). In the multivariate analysis, the reduction in PPH (EXPOSED vs NON EXPOSED) after changing the oxytocin batch was significant (OR 0.38 [0.14-0.91], p = 0.039).

Conclusion: Changing oxytocin batches during this hot period reduced significantly the PPH rate and maternal morbidity in our experience.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejogrb.2021.01.019DOI Listing

Publication Analysis

Top Keywords

pph exposed
12
pph
10
exposed
9
postpartum hemorrhage
8
oxytocin exposed
8
exposed exposed
8
exposed year
8
changing oxytocin
8
oxytocin
5
hemorrhage oxytocin
4

Similar Publications

Association between psychopharmacotherapy and postpartum hemorrhage.

AJOG Glob Rep

November 2024

Northwell, New Hyde Park, NY (Jackson, Kouba, Meirowitz, Keller, Bracero, and Blitz).

Background: Prior studies evaluating the relationship between psychopharmacotherapy (PPT), and postpartum hemorrhage (PPH) have yielded inconsistent findings. Clarifying this potential relationship is important for effective counseling and risk stratification.

Objectives: Our primary objective was to evaluate the association between prenatal exposure to PPT (any drug class) and the occurrence of PPH requiring transfusion of packed red blood cells (PPH+pRBC) after systematically adjusting for known hemorrhage risk factors at the time of admission for delivery.

View Article and Find Full Text PDF

Introduction: Although Omega-3 is thought to have anticoagulative properties, the potential untoward effects of Omega-3 during pregnancy have not been investigated. No previous studies have been made to specifically assess its effect on postpartum hemorrhage (PPH). Our aim was to determine if an association exists between Omega-3 intake during pregnancy and profuse PPH or massive PPH.

View Article and Find Full Text PDF

Atomically precise alkynyl-protected AgCu nanoclusters: synthesis, structure analysis, and electrocatalytic CO reduction application.

Nanoscale

September 2024

New Energy Research Institute, School of Environment and Energy, South China University of Technology, Guangzhou Higher Education Mega Center, Guangzhou, 510006, China.

Article Synopsis
  • Researchers synthesized and analyzed the structure of AgCu(CCAr)(PPh)Cl nanoclusters, which are composed of silver and copper and show unique absorbance features and superatomic properties.
  • Using single-crystal X-ray diffraction, they found that AgCu has an icosahedral metal core connected to tetrahedra, leading to impressive electrocatalytic performance in CO reduction, showing 95.26% efficiency and 257.2 mA cm at -1.3 V.
  • The study revealed that the high selectivity for CO stems from the removal of a ligand on the Ag atom, showcasing the benefits of using precise metal nanoclusters to explore the structure-performance relationships in catalysis.
View Article and Find Full Text PDF

Homogeneous gold catalysis has attracted much recent attention due to diverse activation modes of gold(i) towards unsaturated organic groups. Because of attractive aurophilic interaction, structural transformations of metalated species into high nuclear clusters are often proposed in gold catalysis, while to date little is known about their assembly behaviors and catalytic activity. In this work, based on stoichiometric Au(i)-mediated enyne cyclization reactions, we achieve a discrete vicinal dicarbanion-centered Au intermediate and three assembled Au, Au, and Au clusters held together by several aryl dicarbanions.

View Article and Find Full Text PDF

Previous studies suggest an association between late pregnancy exposure to selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs) and increased postpartum hemorrhage (PPH) risk. This is the first pregnancy registry study to compare PPH outcomes among women with psychiatric illness exposed or unexposed to SSRIs/SNRIs proximate to delivery. This study used data from the National Pregnancy Registry for Psychiatric Medications to evaluate the relationship between SSRI/SNRI exposure in late pregnancy and PPH risk.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!