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Impact of water, sanitation, and hygiene indicators on enteric viral pathogens among under-5 children in low resource settings.
Sci Total Environ
January 2025
Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Poor water, sanitation, and hygiene (WASH) are the primary risks of exposure to enteric viral infection. Our study aimed to describe the role of WASH conditions and practices as risk factors for enteric viral infections in children under 5. Literature on the risk factors associated with all-cause diarrhea masks the taxa-specific drivers of diarrhea from specific pathogens, limiting the application of relevant control strategies.
View Article and Find Full Text PDFAnterior pituitary gland volume mediates associations between adrenarche and changes in transdiagnostic symptoms in youth.
Dev Cogn Neurosci
January 2025
Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USA; Department of Pharmacology & Neuroscience, Creighton University, Omaha, NE, USA.
The pituitary gland (PG) plays a central role in the production and secretion of pubertal hormones, with documented links to the increase in mental health symptoms during adolescence. Although literature has largely focused on examining whole PG volume, recent findings have demonstrated associations among pubertal hormone levels, including dehydroepiandrosterone (DHEA), PG subregions, and mental health symptoms during adolescence. Despite the anterior PG's role in DHEA production, studies have not yet examined potential links with transdiagnostic symptomology (i.
View Article and Find Full Text PDFBackground: Noise-induced hearing loss (NIHL) in children is a growing public health concern due to increased exposure to high noise levels in various environments. Early intervention is crucial to prevent long-term developmental and social impacts. This study evaluates the effectiveness of earmuffs as a protective intervention in managing NIHL in children.
View Article and Find Full Text PDFFactors affecting the direct red cell effect on thrombosis: Hematocrit dilution and injury patterns.
J Trauma Acute Care Surg
December 2024
From the Department of Surgery, University of Cincinnati, Cincinnati, Ohio.
Background: Red blood cell (RBC) aggregation can be initiated by calcium and tissue factor, which may independently contribute to microvascular and macrovascular thrombosis after injury and transfusion. Previous studies have demonstrated that increased blood storage duration may contribute to thrombotic events. The aims of this study were to first determine the effect of blood product components, age, and hematocrit (HCT) on the aggregability of RBCs, followed by measurement of RBC aggregability in two specific injury models including traumatic brain injury (TBI) and hemorrhagic shock.
View Article and Find Full Text PDFMicroSphere 3D Structures Delay Tissue Senescence through Mechanotransduction.
ACS Nano
January 2025
Department of Orthopedics, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Soochow, Jiangsu 215000, China.
The extracellular matrix (ECM) stores signaling molecules and facilitates mechanical and biochemical signaling in cells. However, the influence of biomimetic "rejuvenation" ECM structures on aging- and degeneration-related cellular activities and tissue repair is not well understood. We combined physical extrusion and precise "on-off" alternating cross-linking methods to create anisotropic biomaterial microgels (MicroRod and MicroSphere) and explored how they regulate the cell activities of the nucleus pulposus (NP) and their potential antidegenerative effects on intervertebral discs.
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