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Performance of diagnostic algorithms in patients with invasive pulmonary aspergillosis.
Clin Infect Dis
December 2024
BioTechMed-Graz, Graz, Austria.
Article Synopsis
- Invasive pulmonary aspergillosis (IPA) is increasingly affecting critically ill ICU patients who lack traditional risk factors, complicating diagnosis due to histological evidence challenges.
- A study analyzed 202 patients across nine centers, comparing existing classification criteria (EORTC-MSG, FUNDICU, Asp-ICU) for diagnosing IPA and their effectiveness in identifying cases confirmed by histology.
- Findings revealed that EORTC-MSG was highly effective in patients with known risk factors, while the FUNDICU criteria's accuracy improved when including factors like ARDS and post-cardiac surgery complications, enhancing its predictive performance.
Mycobiome analyses of critically ill COVID-19 patients.
Microbiol Spectr
December 2024
University of Manchester, Manchester, United Kingdom.
Coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) is a life-threatening complication in patients with severe COVID-19. Previously, acute respiratory distress syndrome in patients with COVID-19 has been associated with lung fungal dysbiosis, evidenced by reduced microbial diversity and colonization. Increased fungal burden in the lungs of critically ill COVID-19 patients is linked to prolonged mechanical ventilation and increased mortality.
View Article and Find Full Text PDFRisk factors associated with invasive pulmonary aspergillosis in severe COVID-19 patients: a casecontrol study.
Medicina (B Aires)
December 2024
Área de Investigación en Medicina Interna, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Introduction: Since the onset of the COVID-19 pandemic, cases of COVID-19-associated pulmonary aspergillosis (CAPA) have been described. Possible risk factors for the development of this condition have been proposed, although evidence in Latin American populations is limited. The objectives were to identify risk factors for the development of CAPA and describe the characteristics of this infection.
View Article and Find Full Text PDFCase report: Unveiling the silent threat in the ICU - a case of disseminated invasive aspergillosis in a patient with fulminant myocarditis.
Front Immunol
December 2024
Fourth Department of Critical Care Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China.
Invasive aspergillosis (IA) significantly increases mortality in critically ill patients in the ICU and its occurrence is closely related to immunocompromise. Dissemination of IA is easily misdiagnosed and mistreated due to its ability to invade multiple systems throughout the body and lack of typical clinical manifestations. In this case, a 25-year-old previously healthy woman was hospitalized with fulminant myocarditis and treated with veno-arterial extracorporeal membrane pulmonary oxygenation (VA-ECMO) support and intravenous acyclovir, high-dose methylprednisolone, and immunoglobulin.
View Article and Find Full Text PDFFrom Hemorrhagic Shock to Postoperative Complications: Anesthesia, Intensive Care, and Surgical Management of a Young Male With Pulmonary Aspergillosis.
Cureus
November 2024
Anesthesia and Critical Care, County Clinical Emergency University/Faculty of Medicine, Lucian Blaga University, Sibiu, ROU.
Pulmonary aspergillosis is a life-threatening condition, especially for individuals with predisposing factors such as prior tuberculosis, smoking, and immune impairment. This case report describes the management of a 33-year-old male with a history of cured tuberculosis and active pulmonary aspergillosis who developed hemorrhagic shock following severe hemoptysis. Initial management included blood transfusion and the administration of tranexamic acid.
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