AI Article Synopsis
- The study investigates the link between the PER2 gene and systemic lupus erythematosus (SLE), focusing on specific genetic variations (SNPs) that may influence susceptibility to the disease.
- A total of 492 SLE patients and 493 healthy individuals were analyzed using advanced genotyping techniques, revealing significant differences in a particular SNP (rs11894491) between the two groups.
- The findings suggest that variations in the PER2 gene could play a role in both the risk of developing SLE and its clinical symptoms, highlighting its importance in understanding the disease's mechanisms.
Article Abstract
The circadian clock plays a crucial role in the progress of systemic lupus erythematosus (SLE). In this study, we performed a case-control study to explore the association between 2 (PER2) gene single nucleotide polymorphisms (SNPs) and the susceptibility of systemic lupus erythematosus (SLE). A total of 492 SLE patients and 493 healthy controls were included. The improved multiple ligase detection reaction (iMLDR) was used for genotyping. The correlations between four SNPs of PER2 (rs10929273, rs11894491, rs36124720, rs934945) and the genetic susceptibility and clinical manifestations of SLE were analyzed. Significant differences were observed in the distributions of allele frequencies and genotype under dominant model in rs11894491 between SLE patients and controls ( = 0.030, = 022, respectively). We hypothesized that PER2 gene SNPs was related to the genetic susceptibility and clinical manifestations, implying the potential role of PER2 in the pathogenesis of SLE.
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| http://dx.doi.org/10.1177/0961203321989794 | DOI Listing |
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