AI Article Synopsis
- Researchers have developed nanoparticles that enhance chemodynamic therapy by utilizing the cancer cells' own hydrogen peroxide (H2O2).
- These nanoparticles use high-molecular-weight DNA as a compatible carrier to load a large amount of manganese ions (Mn2+).
- This approach allows for efficient delivery and release of Mn2+ within cancer cells, leading to increased toxicity through a Fenton-like reaction.
Article Abstract
A kind of nanoparticle is developed for highly efficient chemodynamic therapy that only relies on the endogenous H2O2 of cancer cells. For this nanoparticle, high-molecular-weight DNA is used as the biocompatible carrier to load abundant Mn2+ ions. Therefore, the resultant Mn-DNA coordination nanoparticles can efficiently deliver and sensitively release Mn2+ in cancer cells, resulting in high toxicity through the Fenton-like reaction.
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| http://dx.doi.org/10.1039/d0cc08191d | DOI Listing |
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