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http://dx.doi.org/10.1093/jmcb/mjab005 | DOI Listing |
Sci Rep
January 2025
Department of Gynecology, Guilin People's Hospital, Guilin, 541002, China.
To investigate the efficacy and mechanisms of fractional CO2 laser treatment for Vaginal Relaxation Syndrome (VRS) combined with recurrent bacterial vaginitis. Patients with VRS and recurrent bacterial vaginitis were randomly assigned to an intervention group (n = 60) receiving fractional CO2 laser therapy in addition to metronidazole, or a control group (n = 60) receiving metronidazole alone. Post-treatment assessments included vaginal relaxation, vaginal health index (VHI) scores, lactobacilli distribution, vaginal pH, recurrence rates, and the correlation between lactobacilli distribution and VHI.
View Article and Find Full Text PDFCommun Biol
January 2025
Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, E-28029, Spain.
The frequency of mitochondrial DNA haplogroups (mtDNA-HG) in humans is known to be shaped by migration and repopulation. Mounting evidence indicates that mtDNA-HG are not phenotypically neutral, and selection may contribute to its distribution. Haplogroup H, the most abundant in Europe, improved survival in sepsis.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Emergency Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China.
This research aimed to identify novel indicators for sepsis by analyzing RNA sequencing data from peripheral blood samples obtained from sepsis patients (n = 23) and healthy controls (n = 10). 5148 differentially expressed genes were identified using the DESeq2 technique and 5636 differentially expressed genes were identified by the limma method(|Log2 Fold Change|≥2, FDR < 0.05).
View Article and Find Full Text PDFBr J Anaesth
January 2025
Department of Anaesthesiology, Perioperative and Pain Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Background: Spread of local anaesthetic solution in the paravertebral space after erector spinae plane block (ESPB) is variable. We evaluated whether paravertebral spread of local anaesthetic is affected by patient position after ESPB.
Methods: We randomised 84 patients to receive ESPB at T with a mixture of 0.
J Sci Med Sport
December 2024
Alliance for Research in Exercise, Nutrition, and Activity (ARENA), University of South Australia, Australia.
Objective: This study aimed to systematically investigate whether polarized or non-polarized training leads to greater physiological and performance adaptations in cyclists.
Design: A systematic review and meta-analysis were conducted, focusing on interventions categorized as polarized, non-polarized, or unclear. Inclusion criteria required participants to be at least recreationally trained cyclists (VO ≥ 59 ml/kg/min) and interventions lasting > 4 weeks.
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