Herein, we developed the first visible-light-induced direct Csp-H radical 2,2,2-trifluoroethylation of coumarins with commercially available and cheap reagent CFCHI at room temperature. This transformation proceeded smoothly under mild conditions and showed excellent functional group compatibility. The synthetic value of the protocol was also demonstrated by the successful functionalization of several pharmaceuticals.
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| http://dx.doi.org/10.1021/acs.joc.0c02739 | DOI Listing |
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