Twelve hitherto unknown tandem prenylated -hydroxybenzoic acid derivatives, namely, oberoniamyosurusins A-L, together with five known derivatives, were isolated from an EtOH extract of the whole parts of the plant . Compounds , , and exhibited moderate inhibitory activity against subsp. ATCC29213 with MIC values ranging from 7.6 to 23 μg/mL. To determine the biosynthetic pathway of this class of tandem prenyl-substituted compounds, the full-length transcriptome of was sequenced, yielding 19.09 Gb of clean data and 10 949 nonredundant sequences. Two isoforms of -hydroxybenzoic acid prenyltransferases were annotated and functionally characterized as the enzymes that might be involved in the biosynthesis of nervogenic acid () in .
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