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High-intensity focused ultrasound: an innovative approach for micro-manipulation of demineralized dentine.
J Transl Med
January 2025
Dental School, The University of Western Australia, 17 Monash Avenue, Nedlands, WA, 6009, Australia.
Background: Treatment of deep carious lesions poses significant challenges in dentistry, as complete lesion removal risks compromising pulp vitality, while selective removal often reduces the longevity of restorations. Herein, we propose a minimally invasive approach using High-Intensity Focused Ultrasound (HIFU) for microscale removal of carious dentine. Concurrently, HIFU's antimicrobial effects against associated cariogenic biofilms and the corresponding thermal and biological impacts on surrounding tissues were investigated.
View Article and Find Full Text PDFStructural basis of THC analog activity at the Cannabinoid 1 receptor.
Nat Commun
January 2025
Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Tetrahydrocannabinol (THC) is the principal psychoactive compound derived from the cannabis plant Cannabis sativa and approved for emetic conditions, appetite stimulation and sleep apnea relief. THC's psychoactive actions are mediated primarily by the cannabinoid receptor CB. Here, we determine the cryo-EM structure of HU210, a THC analog and widely used tool compound, bound to CB and its primary transducer, G.
View Article and Find Full Text PDFEffect of fructooligosaccharides in full-hydrated lactic acid bacteria membrane models during thermal stress: A molecular simulation study.
Food Res Int
January 2025
University of Coimbra, CERES, Department of Chemical Engineering, Rua Sílvio de Lima, Coimbra 3030-790, Portugal. Electronic address:
Fructooligosaccharides (FOS) are a promising choice for cryoprotection of lactic acid bacteria (LAB). However, the mechanism by which this protection takes place is not well understood. Molecular simulation is a key tool for gathering insights into complex physicochemical problems like this.
View Article and Find Full Text PDFEnhancing Surgical Curriculum: Trainees' Perspectives on Laparoscopic Simulation and Assessment.
Cureus
January 2025
Medical Education, Aga Khan University, Karachi, PAK.
Introduction Laparoscopic simulation has been used in many curricula. The United Kingdom (UK) surgical curriculum lacks summative assessment for laparoscopic skills. This study explores surgical trainees' perceptions of using simulated laparoscopic assessment as a summative tool in the UK.
View Article and Find Full Text PDFComputational modeling of fear and stress responses: validation using consolidated fear and stress protocols.
Front Syst Neurosci
December 2024
Universidade Federal de Goias, School of Electrical, Mechanical and Computer Engineering, Goiânia, Brazil.
Dysfunction in fear and stress responses is intrinsically linked to various neurological diseases, including anxiety disorders, depression, and Post-Traumatic Stress Disorder. Previous studies using in vivo models with Immediate-Extinction Deficit (IED) and Stress Enhanced Fear Learning (SEFL) protocols have provided valuable insights into these mechanisms and aided the development of new therapeutic approaches. However, assessing these dysfunctions in animal subjects using IED and SEFL protocols can cause significant pain and suffering.
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