A 7-year-old boy presented to a community emergency department (ED) after sustaining a minor fall. Although he was found to have a normal neurologic examination, additional history revealed the patient had been having mild intermittent headaches and dizziness in the months preceding the fall. The emergency clinicians ordered neuroimaging, which demonstrated a right cerebellar mass, ultimately diagnosed as atypical rhabdoid/teratoid tumor. Atypical rhabdoid/teratoid tumor is a rare, aggressive brain tumor with a poor prognosis. The objectives of this case report are to emphasize the importance of detailed history with pediatric head trauma, in particular on reassessment, and to discuss briefly the epidemiology and management of atypical teratoid rhabdoid tumor.
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http://dx.doi.org/10.1002/emp2.12353 | DOI Listing |
Brain Spine
November 2024
Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.
Atypical teratoid/rhabdoid tumors (AT/RTs) of the central nervous system (CNS) are rare and aggressive, typically occurring in early childhood or infancy, with adult cases being extremely rare. These tumors are associated with the inactivation of the integrase interactor 1 (INI1) gene. The prognosis is poor, worsening significantly if metastasis is detected at diagnosis.
View Article and Find Full Text PDFNeuro Oncol
December 2024
Department of Neurological Surgery, Weill Cornell Medicine, New York, NY 10065, USA.
Background: Inhibitors targeting cyclin-dependent kinases 4 and 6 (CDK4/6), crucial for cell cycle regulation, have shown promise in early-stage studies for treating central nervous system (CNS) tumors. However, challenges such as limited CNS penetration, optimal treatment duration, and systemic side effects have impeded their clinical translation for pediatric brain tumors (PBTs).
Methods: We evaluated the potency of CDK4/6 inhibitors across various PBTs cell lines, focusing particularly on palbociclib against atypical teratoid rhabdoid tumor (ATRT) with cell viability assays and gene expression analysis.
Brain Spine
November 2024
Department of Neurosurgery, General Hospital of Nikaia 'Agios Panteleimon', 18454, Athens, Greece.
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