Purpose: To report long term results of two cases treated with topical cyclosporin A 1% for keratitis associated with autoimmune polyglandular syndrome (APS1).
Observations: A 25-year-old male and a 17-year-old female were referred from endocrinology as APS1-related autoimmune keratitis. Extended-duration treatment with topical cyclosporin A (CsA) 1% was used for 24 and 18 months, respectively. The first patient had improved best-corrected visual acuity (BCVA) from 20/200 and 20/300 in right and left eye to 20/60 in both eyes with markedly improved corneal opacification, while the second patient had improved BCVA from 20/400 and 20/300 in right and left eye to 20/160 in both eyes with persistent central stromal scarring in the right eye and discrete areas of stromal scarring in the left eye.
Conclusions And Importance: Long-term topical CsA 1% offers a valuable option for treatment of APS1-related autoimmune keratitis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809181 | PMC |
| http://dx.doi.org/10.1016/j.ajoc.2020.101009 | DOI Listing |
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