HLA-B27 has an established relationship with the development of ankylosing spondylitis (AS). After reviewing the HLA-B genotype from 407 Chinese subjects (318 patients and 89 sex-matched controls), we found that 252 patients and 32 controls were HLA-B27(+) and that HLA-B27:04 was the dominant HLA-B27 subtype ( = 224). In all participants, HLA27:04 homozygous were only detected in two patients. In the HLA-B27(+) group, HLA-B40 was observed in 51 cases and one control ( < 0.05, OR = 7.87, 95% CI 1.05-59.0); of these, the most genotype was HLA-B27:04/B40:01( = 38). Two hundred thirty-nine patients' clinical information was recorded. Cases with HLA-B27/B46 had more peripheral joint involvement (OR = 3.95, 95% CI 1.77-8.79) in HLA-B27(+) AS. HLA-B15:02 may be a significant risk element to peripheral joint involvement ( < 0.05) in HLA-B27(-) patients. Therefore, we believe HLA-B40:01, HLA-B46:01, and HLA-B15:02 can be the test indicators for AS diagnostic value.
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| http://dx.doi.org/10.3389/fmed.2020.568790 | DOI Listing |
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