AI Article Synopsis
- Cells respond to mechanical and chemical stimuli by changing their shape and internal organization, a process known as mechanotransduction, which is vital for various cellular functions.
- Recent research emphasizes the nucleus as a key player in sensing mechanical changes and influencing how cells react.
- This review will cover the relationship between the cytoskeleton and nucleus in response to mechanical conditions and how disruptions in this connection can impact health and disease, along with technologies for studying these processes.
Article Abstract
Cells sense a variety of different mechanochemical stimuli and promptly react to such signals by reshaping their morphology and adapting their structural organization and tensional state. Cell reactions to mechanical stimuli arising from the local microenvironment, mechanotransduction, play a crucial role in many cellular functions in both physiological and pathological conditions. To decipher this complex process, several studies have been undertaken to develop engineered materials and devices as tools to properly control cell mechanical state and evaluate cellular responses. Recent reports highlight how the nucleus serves as an important mechanosensor organelle and governs cell mechanoresponse. In this review, we will introduce the basic mechanisms linking cytoskeleton organization to the nucleus and how this reacts to mechanical properties of the cell microenvironment. We will also discuss how perturbations of nucleus-cytoskeleton connections, affecting mechanotransduction, influence health and disease. Moreover, we will present some of the main technological tools used to characterize and perturb the nuclear mechanical state.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820809 | PMC |
| http://dx.doi.org/10.3389/fbioe.2020.596746 | DOI Listing |
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