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Evaluation of the efficacy of PD‑1/PD‑L1 inhibitor plus bevacizumab and chemotherapy for the treatment of patients with driver gene‑negative advanced‑stage lung adenocarcinoma: A retrospective cohort study.
Oncol Lett
January 2025
Department of Thoracic Surgery, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610000, P.R. China.
Driver gene-negative advanced-stage lung adenocarcinoma is associated with a poor prognosis and insufficient treatment options. The present study aimed to evaluate the efficacy and safety profile of a programmed cell death protein 1/programmed death-ligand 1 inhibitor plus bevacizumab and chemotherapy (PBC) regimen for the treatment of patients with driver gene-negative advanced-stage lung adenocarcinoma under real-world clinical conditions. Data from 65 patients with advanced-stage lung adenocarcinoma without sensitizing epidermal growth factor receptor, ALK receptor tyrosine kinase or ROS proto-oncogene 1 receptor tyrosine kinase mutations who received a PBC regimen or only a BC regimen were reviewed in the present retrospective cohort study.
View Article and Find Full Text PDFComparison of microvascular decompression and percutaneous balloon compression efficacy in patients with V2 idiopathic trigeminal neuralgia.
Front Neurol
October 2024
Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Article Synopsis
- The study compares the effectiveness and long-term outcomes of two surgical treatments, microvascular decompression (MVD) and percutaneous balloon compression (PBC), for idiopathic trigeminal neuralgia affecting the maxillary branch in 157 patients over three years.
- Both MVD and PBC showed similar rates of pain relief immediately after surgery and at the 12-month mark, though MVD had notably fewer complications such as facial numbness and masticatory weakness.
- MVD provided a longer duration of pain relief compared to PBC, with most patients experiencing recurrence of symptoms within 1-2 years post-surgery.
Evaluation of patients with positive anti-mitochondiral antibody and normal alkaline phosphatase levels for primary biliary cholangitis.
Acta Gastroenterol Belg
August 2024
Department of Internal Medicine, Division of Gastroenterology, Ege University, Izmir, Turkey.
Primary Biliary Cholangitis (PBC) is a chronic cholestatic liver disease typically diagnosed by elevated cholestatic liver enzymes and a positive anti-mitochondrial antibody (AMA) test. The clinical importance of AMA positivity in patients with normal cholestatic liver enzymes is unclear. The aim of this study was to determine the relationship between PBC and AMA positivity detected in individuals with normal cholestatic enzyme levels.
View Article and Find Full Text PDFDelta-radiomics features of ADC maps as early predictors of treatment response in lung cancer.
Insights Imaging
August 2024
Translational Lung Research Center (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany.
Objective: Investigate the feasibility of detecting early treatment-induced tumor tissue changes in patients with advanced lung adenocarcinoma using diffusion-weighted MRI-derived radiomics features.
Methods: This prospective observational study included 144 patients receiving either tyrosine kinase inhibitors (TKI, n = 64) or platinum-based chemotherapy (PBC, n = 80) for the treatment of pulmonary adenocarcinoma. Patients underwent diffusion-weighted MRI the day prior to therapy (baseline, all patients), as well as either + 1 (PBC) or + 7 and + 14 (TKI) days after treatment initiation.
Wits Transplant Unit Annual Report 2022: Adult and paediatric liver transplantation.
S Afr Med J
April 2024
Wits Donald Gordon Medical Centre, University of the Witwatersrand, Johannesburg, South Africa; Department of Surgery, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
In 2022, the Wits Transplant Unit performed 57 liver transplants: 33/57 adult (58%) and 24/57 paediatric (42%) recipients. At the beginning of 2022, 28 candidates were on the adult waitlist. Forty-six candidates were added to the waitlist during the year.
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