In the recent era, a liver syndrome that causes any damage in life capacity is exceptionally normal everywhere throughout the world. It has been found that liver disease is exposed more in young people as a comparison with other aged people. At the point when liver capacity ends up, life endures just up to 1 or 2 days scarcely, and it is very hard to predict such illness in the early stage. Researchers are trying to project a model for early prediction of liver disease utilizing various machine learning approaches. However, this study compares ten classifiers including A1DE, NB, MLP, SVM, KNN, CHIRP, CDT, Forest-PA, J48, and RF to find the optimal solution for early and accurate prediction of liver disease. The datasets utilized in this study are taken from the UCI ML repository and the GitHub repository. The outcomes are assessed via RMSE, RRSE, recall, specificity, precision, G-measure, F-measure, MCC, and accuracy. The exploratory outcomes show a better consequence of RF utilizing the UCI dataset. Assessing RF using RMSE and RRSE, the outcomes are 0.4328 and 87.6766, while the accuracy of RF is 72.1739% that is also better than other employed classifiers. However, utilizing the GitHub dataset, SVM beats other employed techniques in terms of increasing accuracy up to 71.3551%. Moreover, the comprehensive outcomes of this exploration can be utilized as a reference point for further research studies that slight assertion concerning the enhancement in extrapolation through any new technique, model, or framework can be benchmarked and confirmed.
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http://dx.doi.org/10.1155/2020/6680002 | DOI Listing |
Pediatr Infect Dis J
March 2025
Department of Pediatrics and Intensive Care Medicine.
Background: To evaluate the disease burden, risk of complications and mortality in children with viral detection during the peri-liver transplant period.
Methods: A retrospective cohort study was conducted between January 2020 and December 2023 at a tertiary university hospital. Children who underwent multiplex polymerase chain reaction testing from 7 days before to 14 days after liver transplantation were included.
Hepatology
March 2025
Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China.
Background And Aims: Portal vein tumor thrombosis (PVTT), an indicator of clinical metastasis, significantly shortens hepatocellular carcinoma (HCC) patients' lifespan, and no effective treatment has been established. We aimed to illustrate mechanisms underlying PVTT formation and tumor metastasis, and identified potential targets for clinical intervention.
Approach And Results: Multi-omics data of 159 HCC patients (including 37 cases with PVTT) was analyzed to identify contributors to PVTT formation and tumor metastasis.
Liver fibrosis is a global health problem. IL-17A has proven profibrogenic properties in liver disease making it an interesting therapeutic target. IL-17A is regulated by RORγt and produced by Th17 CD4+ and γδ-T cells.
View Article and Find Full Text PDFSci Adv
March 2025
Department of Radiology, Tongji Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai 200065, China.
Liver fibrosis is an inevitable stage in the progression of most chronic liver diseases. Early diagnosis and treatment of liver fibrosis are crucial for effectively managing chronic liver conditions. However, there lacks a noninvasive and sensitive imaging method capable of early assessing fibrosis activity.
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March 2025
Tasmanian School of Medicine, College of Health and Medicine, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania 7000, Australia.
Understanding plastics' harmful impacts on wildlife would benefit from the application of hypothesis agnostic testing commonly used in medical research to detect declines in population health. Adopting a data-driven, proteomic approach, we assessed changes in 745 proteins in a free-living nonmodel organism with differing levels of plastic exposure. Seabird chicks heavily affected by plastic ingestion demonstrated a range of negative health consequences: Intracellular components that should not be found in the blood were frequently detected, indicative of cell lysis.
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