Introduction: PCSK9 inhibitors lower low-density lipoprotein (LDL) cholesterol and are efficacious at reducing vascular disease, however questions remain about potential effects on cognitive function.
Methods: We examined the association of genetic variants in with continuous measures of cognitive ability in UK Biobank. Six independent polymorphisms in were used in up to 337,348 individuals.
Results: The allele score was associated with a lower risk of CHD, and weakly with worse log reaction time.
Conclusions: We are unable to rule out meaningful associations of genetic variants with cognition, emphasising the potential need for continued pharmacovigilance for patients currently treated with PCSK9 inhibitors.
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| http://dx.doi.org/10.5114/aoms/127226 | DOI Listing |
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