Introduction: The aim of this randomized controlled experimental study was to evaluate the efficacy of potassium, pH and D-dimer levels in blood, as well as potassium and pH levels in peritoneal lavage fluid, in the early diagnosis of acute mesenteric ischemia.
Material And Methods: This study was conducted at the Istanbul University Center of Experimental Medicine after having received approval from the Istanbul University animal testing ethics committee. Male albino Wistar rats ( = 24; 250 to 350 g) were divided into two control groups and two ischemic groups. Levels of potassium, pH, and D-dimer in blood and levels of potassium and pH in peritoneal lavage fluid were analyzed for 1 h and 2 h after the induced acute mesenteric ischemia procedure. The degree of ischemic injury was determined using the histopathological damage score in tissue samples taken from the terminal ileum.
Results: Ischemic groups had statistically significant differences in potassium and pH in blood and peritoneal lavage fluid compared to non-ischemic groups ( < 0.05). There was no significant difference between control and ischemic groups in terms of D-dimer and histologic grading results after 1 h ( = 0.132, = 0.475 respectively), while there was a significant difference between control and ischemic groups after 2 h ( < 0.05).
Conclusions: The levels of potassium, pH, and D-dimer could be useful in daily practice for the early diagnosis of acute mesenteric ischemia.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7811331 | PMC |
| http://dx.doi.org/10.5114/aoms.2019.84225 | DOI Listing |
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