From a CHCl-soluble extract of the stems of (Anacardiaceae), two new diarylalkanoids, semedienone () and semetrienone (), were isolated. Their structures were elucidated based on NMR spectroscopic data interpretation. These compounds possess strong tyrosinase inhibitory activity with the IC values of 0.033 and 0.11 M, respectively. Docking studies of and with -tyrosinase were carried out to analyze their interactions. Accordingly, semedienone () showed good interactions with the peroxide group and amino acid residues. The biosynthesis of the isolated diarylalkanoids was proposed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801053 | PMC |
| http://dx.doi.org/10.1155/2021/8872920 | DOI Listing |
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Diarylalkanoids as Potent Tyrosinase Inhibitors from the Stems of .
Evid Based Complement Alternat Med
January 2021
Faculty of Chemistry, University of Science, 227 Nguyen Van Cu Street, Ward 4, District 5, Ho Chi Minh City, Vietnam.
From a CHCl-soluble extract of the stems of (Anacardiaceae), two new diarylalkanoids, semedienone () and semetrienone (), were isolated. Their structures were elucidated based on NMR spectroscopic data interpretation. These compounds possess strong tyrosinase inhibitory activity with the IC values of 0.
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