Magnetic FeO nanoparticles were synthesized from maize leaves and plantain peels extract mediators. Particles were characterized, and the inhibitory effects were studied on HeLa cells in vitro using cyclic voltammetry (CV). Voltammograms from the CV show that FeO NPs interaction with HeLa cells affected their electrochemical behavior. The nanoparticles formed with higher Fe/Fe molar ratio (2.8 : 1) resulted in smaller crystallite sizes compared to those formed with lower Fe/Fe molar ratio (1.4 : 1). The particles with the smallest crystallite size showed higher anodic peak currents, whereas the larger crystallite sizes resulted in lower anodic peak currents. The peak currents relate to cell inhibition and are confirmed by the half-maximum inhibitory concentration (IC). The findings show that the particles have a different inhibitory mechanism on HeLa cells ion transfer and are promising to be further exploited for cancer treatment.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787869 | PMC |
| http://dx.doi.org/10.1155/2020/2630735 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription.
Mol Cell
January 2025
Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia; Department of Haematology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Centre for Cancer Research, University of Melbourne, Melbourne, VIC, Australia. Electronic address:
Several transcription inhibitors have been developed as cancer therapies. However, they show modest clinical activity, highlighting that our understanding of the cellular response to transcriptional inhibition remains incomplete. Here we report that potent inhibitors of transcription not only impact mRNA output but also markedly impair mRNA transcript localization and nuclear export.
View Article and Find Full Text PDFRecent progress in nanomaterial-based electrochemical biosensors for hydrogen peroxide detection & their biological applications.
Talanta
December 2024
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, India. Electronic address:
The electrochemical biosensor has brought a paradigm shift in the field of sensing due to its fast response and easy operability. The performance of electrochemical sensors can be modified by coupling them with various metal oxides, nanomaterials, and nanocomposites. Hydrogen peroxide is a short-lived reactive oxygen species that plays a crucial role in various physiological and biological processes.
View Article and Find Full Text PDFA near-infrared multifunctional fluorescent bio-probe with large stokes shift and high quantum yield for effective determination of heavy metal lead and pesticide glyphosate in vitro and vivo.
J Hazard Mater
December 2024
Department of Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of Agricultural Functional Molecule Design and Utilization of Heilongjiang Province, Northeast Agricultural University, Harbin 150030, China. Electronic address:
Heavy metal contamination and pesticide residues pose significant threats to human health and ecosystems. Despite its broad applications, fluorescence imaging technology often struggles in complex ecological and biological environments due to disadvantages of background autofluorescence and low quantum yield. This study introduced a near-infrared (NIR) multifunctional "off-on-off" isophorone-based fluorescent bio-probe, DHB, characterized by a high fluorescence quantum yield (10.
View Article and Find Full Text PDFMTCH2 controls energy demand and expenditure to fuel anabolism during adipogenesis.
EMBO J
January 2025
Department of Immunology and Regenerative Biology, Weizmann Institute of Science, 76100, Rehovot, Israel.
Mitochondrial carrier homolog 2 (MTCH2) is a regulator of apoptosis, mitochondrial dynamics, and metabolism. Loss of MTCH2 results in mitochondrial fragmentation, an increase in whole-body energy utilization, and protection against diet-induced obesity. In this study, we used temporal metabolomics on HeLa cells to show that MTCH2 deletion results in a high ATP demand, an oxidized cellular environment, and elevated utilization of lipids, amino acids, and carbohydrates, accompanied by a decrease in several metabolites.
View Article and Find Full Text PDFA Fluorescent Probe Differentiates Apoptosis from Cysteine-Deprivation Ferroptosis through Imaging of Viscosity and Lipid Droplets.
Chemistry
January 2025
Shiv Nadar University, CHEMISTRY, NH 91, TEHSIL DADRI, GAUSTAM BUDHA NAGAR, 201314, GREATER NOIDA, INDIA.
Since death is an inevitable phenomenon, exploring cell deaths holds importance. During this process, the cellular microenvironment within cells such as pH, polarity, viscosity etc alter. One such microenvironment, viscosity elevates during different cell deaths.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!