AI Article Synopsis
- Four linear nonphenolic diarylheptanoids were synthesized and showed varying antibacterial activity against specific bacteria and a yeast using the disc diffusion method.
- The synthesis involved multiple reactions, including reductions and condensations, resulting in compounds like (4,6)-1,7-diphenylhepta-4,6-dien-3-ol and curcuminoids.
- The antimicrobial activity of these compounds was tested against two gram-positive and four gram-negative bacteria, as well as Candida albicans, demonstrating potential effectiveness within a concentration range of 20-100 μg/disc.
Article Abstract
Four linear nonphenolic diarylheptanoids were synthesized and their antibacterial activities were studied. ( )-2-Me-CBS-catalysed reduction of alnustone with BHSMe gave ( )(-)(4 ,6 )-1,7-diphenylhepta-4,6-dien-3-ol, a natural product. Reduction of alnustone with Na in -BuOH at -15 °C under N atm gave ()-1,7-diphenylhept-5- en-3-one as a Birch-type reduction product. -BuOK catalysed condensation of benzalacetone with propionyl chloride gave (4 ,6 )-5-hydroxy-1,7-diphenylhepta-4,6-dien-3-one, a natural product. (1 ,4 ,6 )-5-Hydroxy-4-phenethyl-1,7-diphenylhepta-1,4,6-trien-3-one, a curcuminoid, was synthesized starting from pentan-2,4-dione in 3 steps. The synthesized chemical compounds were applied against 2 gram-positive bacteria ( and ), 4 gram-negative bacteria ( , , , and ), and 1 yeast (Candida albicans) by the disc diffusion method. All of the synthesized compound exhibited different degrees of antimicrobial activity at concentrations between 20-100 μg/disc against the test organisms.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671216 | PMC |
| http://dx.doi.org/10.3906/kim-1911-61 | DOI Listing |
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