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Challenges of Genomic Testing for Hereditary Breast and Ovarian Cancers. | LitMetric

Challenges of Genomic Testing for Hereditary Breast and Ovarian Cancers.

Appl Clin Genet

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA.

Published: January 2021

AI Article Synopsis

Article Abstract

Completion of genetic testing is increasingly important for the complex care of patients with suspected hereditary breast and ovarian cancers (HBOC) and their at-risk family members. Identification of individuals with pathogenic variants has implications for targeted treatment recommendations, risk reduction strategies, increased surveillance recommendations, as well as the genetic testing of family members, known as cascade testing or screening. Due to advances in technology and decreasing costs, what was once single-gene genetic testing has evolved into large-scale multi-gene panel genomic testing. As germline genomic testing for HBOC becomes more and more available, it is important to identify the challenges that are associated with its use. In this manuscript, we review the current issues faced by germline genomic testing for HBOC which include effectively managing the marked increases in genetic referrals, interpreting the vast amount of information yielded by newer testing methods such as next generation sequencing (NGS), recognizing the need for better cascade screening strategies, potential exacerbation of health disparities and improving support for patients navigating the emotional impact related to positive, negative and indeterminate testing results.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814235PMC
http://dx.doi.org/10.2147/TACG.S245021DOI Listing

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