Introduction: Ovarian cancer (OV) can seriously endanger women's physical and mental health. Serum DKK3 has been used for the diagnosis and prognosis of patients with ovarian cancer. However, the specificity of antibodies may lead to errors in the detection of plasma protein.
Methods: Circulating CD133 cells from blood samples were separated by magnetic microbeads. Serum DKK3 levels were determined by ELISA. The roles of DKK3 in OV cells were analyzed in vitro.
Results: In this study, we found that the CD133 subpopulation in circulating tumor cells can indicate the overall survival rate of OV patients. Serum DKK3 levels were negatively correlated with the number of circulating CD133 cells in OV patients. In addition, we confirmed the inhibitory effect of recombinant human DKK3 (rhDKK3) on OV cells via reversal of the epithelial-mesenchymal transition (EMT) process.
Conclusion: Both serum DKK3 levels and circulating CD133 tumor cells can be used as prognostic markers for patients with ovarian cancer.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814242 | PMC |
| http://dx.doi.org/10.2147/OTT.S288191 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
miR-151a-5p predicts severity of diabetic retinopathy and protects from retinal cell injury by inactivating MAPK signaling via DKK3.
Exp Eye Res
December 2024
Department of Ophthalmology, General Hospital of Southern Theatre Command of PLA, Guangzhou, 510010, China. Electronic address:
Diabetes mellitus (DM) is always accompanied by various complications, where diabetic retinopathy was a serious microvascular complications threatening the visual function of patients. This study evaluated the significance of miR-151a-5p and its effect on DR progression aiming to explore a novel biomarker for disease screening and monitoring. Study enrolled 137 patients with DM and 103 diabetes patients with DR.
View Article and Find Full Text PDFUrinary dickkopf-3 as a predictor for postoperative acute kidney injury in the intensive care unit.
Am J Med Sci
November 2024
Department of Critical Care Medicine, Peking University People's Hospital, No.11 Xizhimen South Street, Xicheng District, Beijing 100044, PR China. Electronic address:
Background: As a life-threatening complication in patients undergoing surgery, acute kidney injury (AKI) is strongly associated with a worse prognosis. Urinary dickkopf-related protein 3 (DKK3) has been identified as a biomarker for predicting postoperative AKI in patients undergoing cardiac surgery.
Objective: To investigate the predictive value of urinary DKK3 on postoperative AKI and develop a clinical model based on the predictor for predicting the development of AKI within seven days for patients undergoing noncardiac surgery.
The effects of therapeutic hypothermia on the expression of DKK3 and myocardial ischemia-reperfusion injury.
Int Immunopharmacol
December 2024
Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221004 Jiangsu, China. Electronic address:
Article Synopsis
- The study investigates how therapeutic hypothermia (TH) affects heart damage caused by ischemia-reperfusion (I/R) injury using rat models and cardiac cells.
- Results show that TH decreases the size of heart damage, lowers serum levels of injury markers, and reduces inflammation and cell death associated with I/R injury.
- TH's protective effects may be linked to the DKK3/Wnt/β-catenin signaling pathway, suggesting potential mechanisms for treating heart conditions.
Identification and validation of diagnostic markers related to immunogenic cell death and infiltration of immune cells in diabetic nephropathy.
Int Immunopharmacol
December 2024
Department of Nephrology, Hangzhou TCM Hospital of Zhejiang Chinese Medical University (Hangzhou Hospital of Traditional Chinese Medicine), Hangzhou 310007, Zhejiang, China. Electronic address:
Introduction: Immunogenic cell death (ICD) is a unique cell death triggered by chemotherapy. However, studies elucidating the potential therapeutic role of ICD and the underlying mechanism in diabetic nephropathy (DN) are limited.
Methods: WGCNA was conducted on the human kidney biopsy data linked to DN, analyzing gene sets associated with ICD.
Peritoneal and renal DKK3 clearance in peritoneal dialysis.
BMC Nephrol
August 2024
Nephrology Section, Medical Clinic 1, University Hospital Bonn, Rheinische Friedrich- Wilhelms Universität Bonn, Venusberg Campus 1, D-53127, Bonn, Germany.
Background: Urinary Dickkopf 3 (DKK3) excretion is a recently established biomarker of renal functional development. Its excretion into the peritoneal cavity has not been reported. We here studied DKK3 in peritoneal dialysis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!