Background: Long-Lasting Insecticidal Nets (LLINs) efficacy could be compromised due to a lot of influences together with user compliance and vector population insecticide resistance status. Thus, this study was to assess the biological efficacy of DuraNet® with the help of the World Health Organization cone bioassay and field experimental hut.
Methods: A laboratory and a semi-field conditions experimental huts against Mosquitoes were conducted in southwestern Ethiopia from September 2015 to January 2016. The bio efficacy of DuraNet® was evaluated using the WHO cone bioassay test and then its field efficacy was evaluated using experimental huts against the malaria vector population.
Results: World Health Organization cone bioassay tests against pyrethroid-resistant led to mean percent mortality and knockdown of 78% and 93%, respectively. Washing of DuraNet® successively reduced its efficacy from 93% knockdown (0 wash) to 45% knockdown (20 washes). Similarly, mean mortality decreased from 84% (0 wash) to 47% (20 washes). A total of 1575 female mosquitoes were collected over 40 nights out of which 1373(87.8%) were , 116 (7.4%) were and 107 (6.8%) were . The mean blood-feeding rate was significantly lower ( < .001) in hut containing unwashed DuraNet® when compared to hut containing untreated DuraNet®. The mean mortality rate was significantly higher ( < .001) in hut containing DuraNet® when compared to hut containing untreated DuraNet®. Unwashed DuraNet® showed the highest personal protection 88.7% and 100% against and , respectively.
Conclusion: Both DuraNet® and PermaNet 2.0 moderate efficacy against a pyrethroid-resistant population of from Ethiopia. The bio efficacy of DuraNet® was found below the WHO recommendation. Therefore, the real impact of the observed insecticide resistance against DuraNet® to be further studied under phase-III trials, the need for new alternative vector control tools remains critical.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809299 | PMC |
| http://dx.doi.org/10.1177/1178630220974730 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficacy of PermaNet Dual compared to Interceptor G2 and PermaNet 3.0 in experimental huts in Siaya County, western Kenya.
Malar J
November 2024
Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya.
Article Synopsis
- Pyrethroid-chlorfenapyr nets, like PermaNet Dual, show better effectiveness against pyrethroid-resistant Anopheles funestus compared to traditional nets in Kenya.
- The study used a rigorous experimental hut trial with a Latin Square design to compare PermaNet Dual and Interceptor G2 in terms of mosquito mortality and blood feeding rates.
- Results indicated that PermaNet Dual was non-inferior to Interceptor G2 for mosquito mortality but had a lower effectiveness in preventing blood feeding compared to PermaNet 3.0, suggesting its potential for use in malaria vector control.
The non-inferiority of piperonyl-butoxide Yorkool G3 insecticide-treated nets compared to Olyset®Plus measured by Anopheles arabiensis mortality in experimental huts in Tanzania.
Malar J
October 2024
Vector Control Product Testing Unit (VCPTU) Ifakara Health Institute, Environmental Health, and Ecological Sciences, P.O. Box 74, Bagamoyo, Tanzania.
Background: Non-inferiority trials are recommended by the World Health Organization (WHO) to demonstrate that health products show comparable efficacy to that of existing standard of care. As part of the WHO Global Malaria Programme (GMP) process of assessment of malaria vector control products, a second-in-class insecticide-treated net (ITN) must be shown to be non-inferior to a first-in-class product based on mosquito mortality. The public health impact of the first-in-class pyrethroid-piperonyl butoxide (PBO) ITN, Olyset Plus, has been demonstrated in epidemiological trials in areas with insecticide-resistant mosquitoes, but there is a need to determine the efficacy of other pyrethroid-PBO nets to ensure timely market availability of nets in order to increase access to ITNs.
View Article and Find Full Text PDFThe bioefficacy of a novel VECTRON™ T500 indoor residual spray formulation in an experimental huts trial against Anopheles gambiae s.l. populations.
Acta Trop
November 2024
Tanzania Plant Health and Pesticides Authority, Pesticides Bioefficacy Section, P.O. Box 3024, Arusha, Tanzania.
The emergence of insecticide resistance and its spread through populations of malaria vectors has decreased the number of insecticides available for control. Insecticide resistance has been observed in vector populations across sub-Saharan Africa in malaria endemic areas. Therefore, new compounds with different modes of action are needed that can be used in the management of resistance.
View Article and Find Full Text PDFSubstrate promiscuity of key resistance P450s confers clothianidin resistance while increasing chlorfenapyr potency in malaria vectors.
Cell Rep
August 2024
Centre for Research in Infectious Diseases (CRID), Medical Entomology Department, P.O. Box 13501, Yaoundé, Cameroon; Department of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L35QA, UK; International Institute of Tropical Agriculture (IITA), P.O. Box 2008, Yaoundé, Cameroon. Electronic address:
Novel insecticides were recently introduced to counter pyrethroid resistance threats in African malaria vectors. To prolong their effectiveness, potential cross-resistance from promiscuous pyrethroid metabolic resistance mechanisms must be elucidated. Here, we demonstrate that the duplicated P450s CYP6P9a/-b, proficient pyrethroid metabolizers, reduce neonicotinoid efficacy in Anopheles funestus while enhancing the potency of chlorfenapyr.
View Article and Find Full Text PDFIndoor residual spraying of experimental huts in Cameroon highlights the potential of Fludora® Fusion to control wild pyrethroid-resistant malaria vectors.
BMC Infect Dis
July 2024
Centre for Research in Infectious Diseases (CRID), P.O. Box 13501, Yaoundé, Cameroon.
Elevated resistance to pyrethroids in major malaria vectors has led to the introduction of novel insecticides including neonicotinoids. There is a fear that efficacy of these new insecticides could be impacted by cross-resistance mechanisms from metabolic resistance to pyrethroids. In this study, after evaluating the resistance to deltamethrin, clothianidin and mixture of clothianidin + deltamethrin in the lab using CDC bottle assays, the efficacy of the new IRS formulation Fludora® Fusion was tested in comparison to clothianidin and deltamethrin applied alone using experimental hut trials against wild free-flying pyrethroid-resistant Anopheles funestus from Elende and field An.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!