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Pym-18a, a novel pyrimidine derivative ameliorates glucocorticoid induced osteoblast apoptosis and promotes osteogenesis via autophagy and PINK 1/Parkin mediated mitophagy induction.
Biochem Pharmacol
January 2025
Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh 201002, India. Electronic address:
Glucocorticoid-induced osteoporosis (GIOP) is the most common type of secondary osteoporosis, marked by reduced bone density and impaired osteoblast function. Current treatments have serious side effects, highlighting the need for new drug candidates. Pyrimidine derivatives have been noted for their potential in suppressing osteoclastogenesis, but their effects on osteogenesis and GIOP remain underexplored.
View Article and Find Full Text PDFFive-Year Comparison Results Between Clinically Severely Affected Tetralogy-of-Fallot Patients Initially Treated by Right Ventricular Outflow Stenting and Pink-Fallot Patients Undergoing Single-Step Correction.
J Cardiovasc Dev Dis
December 2024
Laboratory of X-Ray Endovascular and Reconstructive Cardiovascular Surgery, Department of Cardiovascular Surgery, Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Diseases", Blvd. Named After Academician L.S. Barbarasha, 6, 650002 Kemerovo, Russia.
The Purpose: Evaluation of the short-term and long-term results of a phased correction of the tetralogy of Fallot (ToF) with stenting of the right ventricular outflow tract (RVOT) in comparison with a one-stage total correction (TC) of the defect.
Materials And Methods: Two groups of patients with classical ToF were formed. Group 1 (n = 25; median age = 72 days) was initially represented by children with ToF with a more severe clinical status (median weight = 3.
Association of Patients' Knowledge on the Disease and Its Management with Indicators of Disease Severity and Individual Characteristics in Patients with Chronic Obstructive Pulmonary Disease (COPD): Results from COSYCONET 2.
Patient Prefer Adherence
December 2024
Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Bavaria, Germany.
Background: In patients with chronic diseases, including those with chronic obstructive pulmonary disease (COPD), knowledge on the disease and its self-management is considered as relevant for improving disease control and long-term outcome. We studied to which extent components of knowledge depended on potential predictors, such as participation in educational programs and disease severity. For example, the perception of exacerbations or GOLD grade might modulate the content and reliability of COPD understanding.
View Article and Find Full Text PDFConjunctival rhinosporidiosis mimicking pyogenic granuloma: A case report.
Int J Surg Case Rep
December 2024
Department of Internal Medicine, Hawassa University Comprehensive Specialized Hospital, Hawassa, Sidama, Ethiopia.
Introduction And Importance: Rhinosporidiosis is a chronic infectious disease caused by an infection with the sporulating bacterium rhinosporidium seeberi. It mostly affects the nose and nasopharynx mucous membranes, but it can also affect the conjunctiva uncommonly. Ocular rhinosporidiosis is most commonly shown as a polypoid tumor in the palpebral conjunctiva.
View Article and Find Full Text PDFMegastudy testing 25 treatments to reduce antidemocratic attitudes and partisan animosity.
Science
October 2024
Department of Sociology, Stanford University, Stanford, CA 94305, USA.
Article Synopsis
- Scholars are concerned that deep partisan divides among the public pose a risk to American democracy.
- A large study with over 32,000 participants tested 25 different strategies aimed at decreasing partisan animosity and support for undemocratic practices.
- Results showed that highlighting relatable individuals with differing beliefs and emphasizing shared identities were effective at reducing animosity, while correcting misunderstandings about rival views helped lessen support for undemocratic actions.
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