Hydrogen sulfide (HS) is a gaseous molecule that exhibits various biological effects. For example, HS has been recognized as a blood pressure-lowering agent. Presented in this report is a new modifiable platform for HS supply, its preparation and HS release kinetics from a series of structurally diversified thionolactones. Furthermore, the properties of the obtained HS donors were evaluated in both in vitro and in vivo studies. The kinetic parameters of HS release were determined and compared with NaHS and pyrrolidine-2-thione, a thiolactame analog, using a fluorescence detection method based on 7-azido-4-methyl-2H-chromen-2-one probe. We have shown that HS release rates from the developed compounds are controllable through structural modifications. This study shows that both the thiono-lactone ring's size and the presence of a methyl group in the thiono-lactone ring significantly influenced the rate of HS release. Finally, we have found a significant hypotensive response to intravenous administration of the developed donors in anesthetized rats.
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| http://dx.doi.org/10.1016/j.bioorg.2021.104650 | DOI Listing |
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