AI Article Synopsis
- - Copper is a crucial trace element that plays important roles in metalloenzymes and is being studied as a promising alternative to platinum-based anticancer drugs like cisplatin.
- - Copper-based complexes show significant potency and reduced side effects, making them more favorable in cancer treatment due to their broader therapeutic range.
- - The review discusses recent advancements in copper complexes as potential antitumor drug candidates and explores their biochemical and pharmacological mechanisms over the last five years to enhance cancer treatment efficacy.
Article Abstract
Copper is an essential trace element with vital roles in many metalloenzymes; it is also prominent among nonplatinum anticancer metallodrugs. Copper-based complexes are endogenously biocompatible, tenfold more potent than cisplatin, exhibit fewer adverse effects, and have a wide therapeutic window. In cancer biology, copper acts as an antitumor agent by inhibiting cancer via multiple pathways. Herein, we present an overview of advances in copper complexes as 'lead' antitumor drug candidates, and in understanding their biochemical and pharmacological pathways over the past 5 years. This review will help to develop more efficacious therapeutics to improve clinical outcomes for cancer treatments.
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| http://dx.doi.org/10.1016/j.drudis.2021.01.015 | DOI Listing |
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