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Rates and Predictors of Malignancy in Bethesda III and IV Thyroid Nodules: A Prospective Study.
Cureus
December 2024
Internal Medicine, University of Alexandria, Alexandria, EGY.
Aim: Thyroid nodules, based on high-resolution ultrasonography (HRUS), are among the most common endocrine abnormalities that affect the general population because of their high estimated prevalence rates. Fine needle aspiration cytology (FNAC) is a safe, cost-effective modality to differentiate between benign and malignant thyroid nodules based on the Bethesda System for Reporting Thyroid Cytopathology (BSRTC), thus avoiding unnecessary surgery. However, categories III and IV of BSRTC remain a controversial issue in clinical practice, encompassing a wide range of risks of malignancy.
View Article and Find Full Text PDFAim: The aim of the study is to test the null hypothesis that the specificities and sensitivities of the p-value-based significance test for differences between baseline variables and the I test for single trials do not significantly differ in detecting selection bias in randomised controlled trials (RCTs).
Methods: In MS Excel (Microsoft Corp., Redmond, WA, US), 100 trials were simulated, each consisting of two treatment groups (A and B), with 100 subjects in each group.
Enhanced detection of circulating tumor cells using a MUC1 promoter-driven recombinant adenovirus.
Front Oncol
January 2025
The Pq Laboratory of BiomeDx/Rx, Department of Biomedical Engineering, Binghamton University, Binghamton, NY, United States.
Introduction: Circulating tumor cells (CTCs) have attracted significant interest as a biomarker for cancer diagnosis. In this study, we judiciously constructed a recombinant MUC1-dependent adenovirus (rAdF35-MUC1) that can selectively replicate and overexpress copepod super green fluorescent proteins (copGFP) in MUC1-positive tumor cells to investigate its role in the detection of CTCs.
Methods: We conducted a comparative study between rAdF35-MUC1 and the existing hTERT-dependent adenovirus (rAdF35-hTERT).
Prevalence of MRI lesions in men responding to a GP-led invitation for a prostate health check: a prospective cohort study.
BMJ Oncol
August 2023
Urology, University College London Hospitals NHS Foundation Trust, London, UK.
Objective: In men with a raised prostate-specific antigen (PSA), MRI increases the detection of clinically significant cancer and reduces overdiagnosis, with fewer biopsies. MRI as a screening tool has not been assessed independently of PSA in a formal screening study. We report a systematic community-based assessment of the prevalence of prostate MRI lesions in an age-selected population.
View Article and Find Full Text PDFKnowledge and Attitudes of Patients with Rheumatoid Diseases towards Biosimilars.
Mediterr J Rheumatol
December 2024
PanHellenic Federation of Patients, Parents, Caregivers and Friends of Children with Rheumatic Diseases (RHEUMAZIN), Athens, Greece.
Objective: To assess patients' understanding and attitudes towards biosimilars in rheumatoid diseases in Greece.
Methods: A convenience sample of patients with rheumatoid diseases who were members of the largest rheumatoid patient association (RHEUMAZIN) in Greece was selected for this survey. Data on patients' knowledge and attitudes towards biosimilars were collected with a web-based questionnaire.
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