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Background: With the clinical integration of sugammadex, a selective relaxant-binding agent, the approach to reversing neuromuscular blockade is revolutionized. Despite its efficacy, sugammadex's adverse reactions range from mild symptoms to severe cases, including anaphylaxis and coagulopathy. Assessing the nature of these reactions using the Food and Drug Administration's Adverse Event Reporting System (FAERS) database is vital for safe anesthetic practice.
View Article and Find Full Text PDFInducible deletion of endothelial cell Efnb2 delays capillary regeneration and attenuates myofibre reinnervation following myotoxin injury in mice.
J Physiol
October 2024
Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA.
Acute injury of skeletal muscle disrupts myofibres, microvessels and motor innervation. Myofibre regeneration is well characterized, however its relationship with the regeneration of microvessels and motor nerves is undefined. Endothelial cell (EC) ephrin-B2 (Efnb2) is required for angiogenesis during embryonic development and promotes neurovascular regeneration in the adult.
View Article and Find Full Text PDFArticle Synopsis
- Acute neuromuscular paralysis in emergency rooms can be caused by various factors, including adverse reactions to medications like glucocorticoids, specifically betamethasone, which is used for allergic conditions.* -
- A case study highlights a young male who developed four-limb paralysis after receiving a betamethasone injection, which was ultimately linked to hypokalemia, a condition characterized by dangerously low potassium levels.* -
- Proper management of paralysis in patients on glucocorticoids is crucial, as it may stem from hypokalemia, and monitoring electrolyte levels, especially potassium, is recommended to prevent severe complications.*
Considerations regarding anesthesia for renal transplantation.
Anesth Pain Med (Seoul)
January 2024
Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
Renal transplantation is a complex surgical procedure requiring meticulous anesthetic planning to ensure patient safety and optimal graft function. In this comprehensive review, we examined various aspects of anesthesia management during renal transplantation, including preoperative, intraoperative, and postoperative care. Preoperative optimization involves the identification and management of risks to mitigate perioperative complications.
View Article and Find Full Text PDFDevelopment of a Gene and Nucleic Acid Delivery System for Skeletal Muscle Administration via Limb Perfusion Using Nanobubbles and Ultrasound.
Pharmaceutics
June 2023
Department of Drug Delivery and Molecular Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan.
Strategies for gene and nucleic acid delivery to skeletal muscles have been extensively explored to treat Duchenne muscular dystrophy (DMD) and other neuromuscular diseases. Of these, effective intravascular delivery of naked plasmid DNA (pDNA) and nucleic acids into muscles is an attractive approach, given the high capillary density in close contact with myofibers. We developed lipid-based nanobubbles (NBs) using polyethylene-glycol-modified liposomes and an echo-contrast gas and found that these NBs could improve tissue permeability by ultrasound (US)-induced cavitation.
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