Direct inhibition of the transcription factor MYC is widely recognized as one of the thorniest challenges in cancer drug discovery. In this issue of Cell Chemical Biology, Boike et al. (2020) discover a covalent MYC inhibitor that selectively targets a single cysteine residue in an unstructured region of the protein.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.chembiol.2020.12.014 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Magnetic-Responsive Biomimetic Nanosystem Coated with Glioma Stem Cell Membranes Effectively Targets and Eliminates Malignant Gliomas.
Biomater Res
December 2024
Department of Neurosurgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu 226001, P.R. China.
Glioblastoma multiforme (GBM) is among the most challenging malignant brain tumors, making the development of new treatment strategies highly necessary. Glioma stem cells (GSCs) markedly contribute to drug resistance, radiation resistance, and tumor recurrence in GBM. The therapeutic potential of nanomaterials targeting GSCs in GBM urgently needs to be explored.
View Article and Find Full Text PDFTransient destabilization of interhemispheric functional connectivity induced by spreading depolarization.
Netw Neurosci
December 2024
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia.
Cortical spreading depolarization (CSD), a slowly propagating wave of transient cellular depolarization, is a reliable cortical response to various brain insults (stroke, trauma, seizures) and underlying mechanism of migraine aura. Little is known about CSD effects on brain network activity. Using undirected (mutual information, MI) and directed (transfer entropy, TE) measures, we studied the dynamics of cross-hemispheric connectivity associated with the development of unilateral CSD in freely behaving rats and the involvement of inhibitory transmission in mechanisms of the coupling changes.
View Article and Find Full Text PDFEffects of transcranial direct current stimulation on modulating executive functions in healthy populations: a systematic review and meta-analysis.
Front Hum Neurosci
December 2024
Department of Physical Education, Xiamen University of Technology, Xiamen, China.
Background: Conventional research has asserted that cognitive function, particularly, response inhibition, is closely related to the inferior frontal cortex (IFC), dorsolateral prefrontal cortex (DLPFC), or orbital frontal cortex (OFC), which belong to the prefrontal cortex (PFC). Different targets of anodal or cathodal transcranial direct current stimulation (a-tDCS or c-tDCS) would affect the experimental results, but the stimulation of the same brain target would produce inconsistent findings.
Purpose: This study aimed to investigate the effects of a-tDCS and c-tDCS applied over the PFC for healthy populations on reactive and proactive control process compared with sham or no tDCS conditions, as assessed using the Stop-signal task (SST) and Go/NoGo (GNG) task performance.
Basigin in cerebrovascular diseases: roles, mechanisms, and therapeutic target potential.
Eur J Pharmacol
December 2024
Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road, Zhengzhou City, Henan Province, 450000, China. Electronic address:
Cerebrovascular diseases are major global health issues, responsible for significant morbidity and mortality. Basigin (additionally called CD147 or EMMPRIN) is a glycosylated transmembrane protein that facilitates intercellular communication. Recent research has highlighted the critical role of Basigin in inducing matrix metalloproteinases (MMPs), which contribute to the progression of cerebrovascular diseases.
View Article and Find Full Text PDFTEG-Guided Anticoagulation Assessment in Deep Vein Arterialization: A Prospective Analysis.
Ann Vasc Surg
December 2024
Division of Vascular and Endovascular Surgery, Massachusetts General Hospital, Boston, MA. Electronic address:
Introduction: Deep Vein Arterialization (DVA) is an innovative surgical technique aimed at enhancing blood flow in compromised limbs facing amputation. Maintenance of flow post-revascularization is crucial to limb salvage. As this is a new technique, no standardized thromboprophylaxis regime is currently established, and post-procedure thromboprophylaxis is at the discretion of the proceduralist.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!