AI Article Synopsis
- - Chronic arsenism is caused by long-term exposure to arsenic from various sources, leading to severe skin conditions and cancers, as seen in three reported cases.
- - Patients initially developed hyperkeratotic lesions on their palms and soles, which eventually spread across their bodies over a period of more than 30 years.
- - Treatment involving oral retinoids, topical 5-fluorouracil, and photodynamic therapy showed positive results in managing the skin issues and cancers, with no signs of malignancy in other organs.
Article Abstract
Chronic arsenism usually occurs after a long-term unawareness of arsenic exposure from environment, occupation, food, and water. We here reported 3 cases with diffused arsenic keratosis and skin cancers derived from long-term arsenic medication ingestion. In these cases, hyperkeratotic skin lesions were initially found on palms and soles, slowly progressed to every part of the skin and lasted maximally for over 30 years. Skin cancers were diagnosed and removed intermittently within decades, but with no malignancies in other organs. Oral retinoids combing with topical 5- fluorouracil and photodynamic treatment yielded a desirable outcome.
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| http://dx.doi.org/10.1097/DAD.0000000000001903 | DOI Listing |
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