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A new twist on superantigen-activated autoimmune disease.
J Clin Invest
January 2025
Division of Rheumatology, Center of Excellence for Intestinal and Immunology Research, University of Alberta, Edmonton, Alberta, Canada.
Superantigen-induced (Sag-induced) autoimmunity has been proposed as a mechanism for many human disorders, without a clear understanding of the potential triggers. In this issue of the JCI, McCarthy and colleagues used the SKG mouse model of rheumatoid arthritis to characterize the role of Sag activity in inflammatory arthritis by profiling arthritogenic naive CD4+ T cells. Within the diseased joints, they found a marked enrichment of T cell receptor-variable β (TCR-Vβ) subsets that were reactive to the endogenously encoded mouse mammary tumor virus (MMTV) Sag.
View Article and Find Full Text PDFChallenges and prospects of LAG-3 inhibition in advanced gastric and gastroesophageal junction cancer: insights from the RELATIVITY-060 trial.
J Gastrointest Oncol
December 2024
Department of Medical Oncology, University Hospital Antwerp, Edegem, Belgium.
Gut know-how: IL-22 from T cells boosts stress resilience.
Immunity
January 2025
Laboratory of Neuroimmunology, School of Life Sciences, Hangzhou 310030, Zhejiang, China; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou 310024, Zhejiang, China. Electronic address:
Immune activation during sustained stress typically worsens stress-related psychopathology. Whether it can enhance stress resilience remains unclear. In this issue of Immunity, Xia, Lu, Lan et al.
View Article and Find Full Text PDFLetter to the editor: Comment on "Natural bioactive compounds-The promising candidates for the treatment of intestinal failure-associated liver disease".
Clin Nutr ESPEN
January 2025
Graduate Program in Neuropsychiatry and Behavioral Sciences, Center for Medical Sciences, Federal University of Pernambuco, Recife-Pernambuco, 50670-901, Brazil; Department of Nutrition, Center for Health Sciences, Federal University of Pernambuco, Recife-Pernambuco.
Potential of traditional Chinese medicine lyophilized powder of in the treatment of hyperuricemia.
World J Clin Cases
December 2024
Department of Ultrasound imaging, The First Affiliated Hospital of Xiamen University, Xiamen 361000, Fujian Province, China.
Traditional Chinese medicine has a long and illustrious history, and with the development of modern science and technology, the research and application of traditional Chinese medicines have continued to progress significantly. Many traditional Chinese medicinal herbs have undergone scientific validation, reinvigorating with new life and vitality, and contributing unique strengths to the advancement of human health. Recently, the discovery that leech total protein extracted from lyophilized powder reduces blood uric acid (UA) levels by inhibiting the activity of xanthine oxidase to decrease UA synthesis and promotes UA excretion by regulating different UA transporters in the kidney and intestine has undoubtedly injected new vitality and hope into this field of research.
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