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Nitrous oxide-induced myeloneuropathy in a Thai adolescent: a case report.
Paediatr Int Child Health
August 2024
Division of Ambulatory Pediatrics (Toxicology), Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Nitrous oxide, an inhalational anaesthetic, is popular with adolescents worldwide as an accessible recreational drug which induces a euphoric effect. However, chronic abuse leads to serious complications such as myeloneuropathy and bone marrow suppression by inactivation of vitamin B. A 17-year-old girl presented with nitrous oxide-induced myeloneuropathy.
View Article and Find Full Text PDFVitamin B12 Deficiency, a Rare Cause of Isolated Thrombocytopenia in Adults.
Cureus
August 2023
Internal Medicine, Mahsa University, Kuala Lumpur, MYS.
Isolated thrombocytopenia in adults is a common clinical problem, often caused by various hematological disorders. However, vitamin B12 deficiency as a rare cause of isolated thrombocytopenia has been rarely reported in the medical literature. This case report aims to highlight the diagnostic challenges associated with atypical presentations of thrombocytopenia and emphasizes the importance of considering nutritional deficiencies, such as vitamin B12 deficiency, in the diagnostic workup.
View Article and Find Full Text PDFImmunological imbalance in microcephalic children with congenital Zika virus syndrome.
Med Microbiol Immunol
December 2022
Department of Microbiology and Parasitology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, 59078-970, Brazil.
Microcephalic children due congenital Zika virus syndrome (CZS) present neurological symptoms already well described. However, several other alterations can also be observed. Here, we aimed to evaluate the immune system of microcephaly CZS children.
View Article and Find Full Text PDFOverall equipment effectiveness, efficiency and slide review analysis of high-end hematology analyzers.
Pract Lab Med
May 2022
Department of Transfusion Medicine & Immunohematology, Christian Medical College, Vellore, Tamil Nadu, India.
This study evaluated and compared the overall equipment effectiveness (OEE), sensitivity, specificity, and efficiency of the high-end hematology analyzers, Yumizen H2500, DxH 800, DxH 900 and XN-9000 (XN-10). A total of 400 anonymized left over's K2 EDTA whole blood samples were analyzed for complete blood count. Of 400 samples, 200 were tested on Yumizen H2500; DxH 800 & DxH 900 while the other 200 were tested on Yumizen H2500 & XN-9000 (XN-10), respectively.
View Article and Find Full Text PDFLong-term metformin therapy and vitamin B12 deficiency: An association to bear in mind.
World J Diabetes
July 2021
Diabetes Research Institute Federation (DRIF), Division of Endocrinology and Diabetes, CTO Alesini Hospital, Department of Systems Medicine, University of Rome Tor Vergata, Rome 00145, Italy.
To date, metformin remains the first-line oral glucose-lowering drug used for the treatment of type 2 diabetes thanks to its well-established long-term safety and efficacy profile. Indeed, metformin is the most widely used oral insulin-sensitizing agent, being prescribed to more than 100 million people worldwide, including patients with prediabetes, insulin resistance, and polycystic ovary syndrome. However, over the last decades several observational studies and meta-analyses have reported a significant association between long-term metformin therapy and an increased prevalence of vitamin B12 deficiency.
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