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THE EFFECTS OF PROCEDURE DURATION AND ATIPAMEZOLE ADMINISTRATION ON HYPERKALEMIA IN TIGERS () AND LIONS () ANESTHETIZED WITH α-2 AGONISTS. | LitMetric

THE EFFECTS OF PROCEDURE DURATION AND ATIPAMEZOLE ADMINISTRATION ON HYPERKALEMIA IN TIGERS () AND LIONS () ANESTHETIZED WITH α-2 AGONISTS.

J Zoo Wildl Med

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA,

Published: November 2020

AI Article Synopsis

  • A study analyzed 40 long anesthetic events in lions and tigers to understand how various factors affect rising plasma potassium (K) concentrations, focusing on anesthetic time and specific medications.
  • Hyperkalemia (high potassium levels) was first observed around 187 minutes into anesthesia and was significantly linked to longer anesthesia times; administering atipamezole earlier helped reduce potassium levels better than later doses.
  • Electrocardiographic issues were found in some animals, particularly lions, who showed higher potassium levels than tigers, highlighting the need for careful electrolyte monitoring during anesthesia in large wild felids.

Article Abstract

A retrospective analysis of 40 extended (>2 hr) anesthetic events in eight lions () and 32 tigers () was performed using a hierarchical linear growth curve model to assess the effects of anesthetic time, α-2 adrenoreceptor agonist dosages, administration of atipamezole, and biochemical parameters on rising plasma K concentrations. Hyperkalemia was first noted at a mean time of 187 min (range: 131-226 min), with time under anesthesia as a statistically significant predictor of K concentration ( < 0.0001). A significant two-way interaction between time and atipamezole administration ( = 0.0082) for rising K concentrations was demonstrated, indicating that administration of atipamezole can mitigate the rise in K concentrations. Administration of atipamezole beyond 150 min of anesthetic time was less effective in reducing K concentrations than if administered earlier. Electrocardiographic abnormalities were noted in eight animals, including three hyperkalemic individuals. Lions developed significantly greater plasma K concentrations than tigers ( = 0.0009) during anesthesia. No biochemical parameter was identified as a significant indicator of which individuals will develop hyperkalemia. Clinicians anesthetizing any large nondomestic felid should monitor electrolytes regularly during anesthetic events; consider early, partial- to full-dose reversal of α-2 agonists; and be prepared to correct potentially life-threatening electrocardiographic abnormalities resulting from hyperkalemia.

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Source
http://dx.doi.org/10.1638/2019-0128DOI Listing

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