Introduction: Chronic rhinitis (CR) is dominated by allergic rhinitis (AR) whose frequency continues to increase. Allergic rhinitis is a public health problem. The distribution of pneumallergens varies according to countries and regions. The epidemiology of pneumallergens, as well as their role in respiratory pathology, remain poorly known in the southern region of Tunisia.
Aim: To evaluate the prevalence of skin-tests positivity of patients with CR in a region of southern Tunisia, to identify the main pneumallergens and to look for an epidemiological and clinical prediction of AR.
Methods: This is a retrospective study of patients with CD and residing in Sfax, performed in the ENT department of Habib Bourguiba hospital over a period of 2 years (2015-2017).
Results: We collected 300 patients. The diagnosis of AR was retained in 109 patients (36.3%). Mites were the most common allergens (67%) followed by dander (38.5%) and olive pollen (31.2%). Study in uni-variate analysis retained young age, presence of drug allergy, frequent sneezing, nasal hyperreactivity triad, nasal pruritus, and pharyngeal signs as predictors of AR. Multivariate analysis included age≤ 30 years (p = 0.005), frequent sneezing (p = 0.005), and pharyngeal signs (p = 0.01).
Conclusion: AR is a common pathology in the Sfax region that mainly affects young people with signs of nasal hyperresponsiveness. The accessibility of the most common pneumallergens to eviction measures opens a better perspective of management.
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World Allergy Organ J
December 2024
Department of Pediatrics, Pediatric Allergy and Pulmonology Unit, University of Chieti-Pescara, Chieti, Italy.
Basophilic granulocytes, containing and releasing histamine after a specific allergy stimulation, are directly involved in IgE-mediated allergic reactions. CD63 is a transmembrane protein of secretory lysosomes of basophils and its upregulation is related with the release of histamine to the extracellular space during IgE-mediated allergic reactions. Basophil activation test (BAT) measures the activation of circulating basophils upon the stimulation of living blood cells with specific allergens.
View Article and Find Full Text PDFRhinology
December 2024
Research Committee of Young Otolaryngologists of the International Federation of Otorhinolaryngological Societies, Paris, France.
Objective: To validate the French version of the Empty Nose Syndrome Index (Fr-ENSI).
Methods: Patients with ENS, chronic rhinitis/rhinosinusitis, and asymptomatic individuals were recruited from April to August 2024. The internal consistency was evaluated with Cronbach-alpha.
Respir Physiol Neurobiol
December 2024
Department of Pathophysiology Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Slovakia. Electronic address:
Background: Allergic rhinitis (AR) is a common cause of chronic cough, linked to dysregulated airway C- and Aδ-fibres through inflammatory mediators. Despite the limited efficacy of current antitussive therapies, recent studies show that the Na1.7 inhibitor can block cough in naïve guinea pigs.
View Article and Find Full Text PDFAm J Otolaryngol
December 2024
University of Illinois Chicago College of Medicine, Department of Otolaryngology-Head and Neck Surgery, 1853 W Polk St, Chicago, IL 60612, USA.
Background: Environmental exposures may be associated with increased severity of chronic rhinosinusitis (CRS). However, research examining associations of traffic related air pollution with CRS is limited. The purpose of this study was to determine the association between residential traffic proximity and CRS with nasal polyposis (CRSwNP) severity in an existing database of adults in the United States.
View Article and Find Full Text PDFVestn Otorinolaringol
December 2024
St. Petersburg Research Institute of Ear, Throat, Nose and Speech, St. Petersburg, Russia.
Currently, targeted biological therapy is an innovative and highly effective approach in the treatment of severe chronic rhinosinusitis with nasal polyps (CRSwNP) associated with T2 inflammation that is uncontrolled by standard treatment methods. The article presents the first experience of long-term observation of a patient who, one year after the start of targeted biological therapy with dupilumab, independently stopped the treatment due to complete relief of symptoms of CRSwNP, despite recommendations to continue therapy to maintain control. At the same time, one year after the refusal of biological therapy, the patient showed persistent clinical remission in relation to the symptoms of CRSwNP, confirmed by the results of videoendoscopic examination of the nasal cavity and computed tomography of the sinuses.
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