The cGMP-dependent protein kinase in (PfPKG) plays multiple roles in the life cycle of the parasite. As a result, this enzyme is a potential target for new antimalarial agents. Existing inhbitors, while potent and active in malaria models are not optimal. This communication describes initial optimization of a structurally distinct class of PfPKG inhibitors.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536641PMC
http://dx.doi.org/10.1039/c9md00511kDOI Listing

Publication Analysis

Top Keywords

cgmp-dependent protein
8
protein kinase
8
discovery isoxazolyl-based
4
isoxazolyl-based inhibitors
4
inhibitors cgmp-dependent
4
kinase cgmp-dependent
4
kinase pfpkg
4
pfpkg plays
4
plays multiple
4
multiple roles
4

Similar Publications

Decapod crustaceans regulate molting through steroid molting hormones, ecdysteroids, synthesized by the molting gland (Y-organ, YO). Molt-inhibiting hormone (MIH), a neuropeptide synthesized and secreted by the eyestalk ganglia, negatively regulates YO ecdysteroidogenesis. MIH signaling is mediated by cyclic nucleotide second messengers.

View Article and Find Full Text PDF

[Molecular mechanism of Xiangsha Liujunzi Decoction in treating chronic atrophic gastritis based on transcriptome sequencing technology].

Zhongguo Zhong Yao Za Zhi

September 2024

Key Laboratory of Traditional Chinese Medicine for Prevention and Control of Regional High Incidence Diseases in Ningxia,Ministry of Education, Ningxia Medical University Yinchuan 750004, China.

Based on transcriptomics technology, this study investigated the molecular mechanisms of Xiangsha Liujunzi Decoction in treating chronic atrophic gastritis(CAG), which were confirmed through experimental validation. The CAG rat model was built by the MNNG composite multi-factor method, followed by a 90-day administration of Xiangsha Liujunzi Decoction. The study measured the rat body mass and 3-hour food intake in each group and observed the pathological changes in gastric tissue using HE staining.

View Article and Find Full Text PDF

Cardiac cGMP Regulation and Therapeutic Applications.

Hypertension

February 2025

Division of Cardiology, Department of Medicine (D.A.K.), Johns Hopkins University School of Medicine, Baltimore, MD.

cGMP plays a central role in cardiovascular regulation in health and disease. It is synthesized by NO or natriuretic peptide activated cyclases and hydrolyzed to 5'GMP by select members of the PDEs (phosphodiesterase) superfamily. The primary downstream effector is cGMP-dependent protein kinase, primarily cGK-1a (cyclic GMP-dependent protein kinase 1 alpha) also known as protein kinase G 1a in the heart and vasculature.

View Article and Find Full Text PDF
Article Synopsis
  • The article in question has been corrected to address errors found in the original publication.
  • The DOI for the corrected article is 10.1371/journal.pone.0303758, which is a unique identifier for academic papers.
  • It emphasizes the importance of maintaining the integrity and accuracy of published research by ensuring corrections are made when necessary.
View Article and Find Full Text PDF

Light sensing is a critical function in most organisms and is mediated by photoreceptor proteins and phototransduction. Although most nematodes lack eyes, some species exhibit phototaxis. In the nematode Caenorhabditis elegans, the unique photoreceptor protein Cel-LITE-1, its downstream G proteins, and cyclic GMP (cGMP)-dependent pathways are required for phototransduction.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!