AI Article Synopsis
- NUT carcinoma is a rare and aggressive cancer linked to a genetic rearrangement on chromosome 15, often resulting in poor prognosis and typically occurring in central locations of the body, such as the lungs.
- A case of a 70-year-old man diagnosed with primary pulmonary NUT carcinoma is described, with a tumor detected in the left lung during routine examination.
- The patient underwent surgery followed by chemotherapy, antiangiogenesis therapy, and radiotherapy, which contributed to an extended lifespan, highlighting the clinical features and treatment approaches for this uncommon disease.
Article Abstract
NUT carcinoma is a rare, high lethal cancer which feature as the rearrangement of the nuclear protein in testis (NUT) gene on chromosome 15q14, and its pathogenesis and treatment is not yet clear, the prognosis is poor. Due to NUT carcinoma often occurred on the middle position of the body, such as eyes, nose and palate, mediastinum, so it is also called NUT midline carcinoma (NMC). In this case, we report a 70 years old man who was diagnosed as primary pulmonary NUT carcinoma in the Department of Thoracic Oncology, West China Hospital of Sichuan University. A tumor was found at the left hilus pulmonis when his physical examination without any symptom. Postoperative pathological showed poorly differentiated carcinoma, confirmed by fluorescence in situ hybridization technique for the NUT carcinoma. After operation, chemotherapy, antiangiogenesis therapy, and radiotherapy were given, and he got a long lifetime. Combined with the literature review, we report the clinical and pathological features, and treatment strategies of the rare pulmonary NUT carcinoma case. .
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849030 | PMC |
| http://dx.doi.org/10.3779/j.issn.1009-3419.2020.102.44 | DOI Listing |
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