Purpose: The value of parotidectomy in older patients is unclear. This study presents a decision model to help resolve this question.
Materials & Methods: A Markov model with Monte Carlo simulation was used to compare outcomes in patients of different ages with pleomorphic adenoma of the parotid gland treated by surgery or surveillance.
Results: In 30-year-old patients, surgery conferred a 3.5-year gain in life expectancy whereas in 75-year-olds, it was only 0.74 months. The expected rate of malignant transformation at age 30 years was 6.5% after surgery and 26.5% after surveillance; at age 65, corresponding rates were 0.8% and 10.7%. Sensitivity analysis showed that age was the only parameter that significantly contributed to life expectancy. The benefit of surgery was restricted in older patients.
Conclusion: Our Markov decision-analysis model suggests that patients older than 65 years with pleomorphic adenoma have a limited survival advantage with surgery compared to surveillance.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.amjoto.2020.102868 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Lateral tongue pleomorphic adenoma in pediatrics: A case report.
Int J Surg Case Rep
January 2025
Oral and Maxillofacial surgery Unit, Department of Dental and Maxillofacial Surgery, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Introduction: Pleomorphic adenoma, the most common benign salivary gland tumor, typically occurs in the parotid region but can also arise in minor salivary glands. Its occurrence in the lateral tongue is infrequent, making this case the first reported from Ethiopia and the second in English literature.
Case Presentation: We present an 11-year-old girl who underwent an excisional biopsy for a tongue swelling lasting 2 years.
Challenges in the Management of Giant Carcinoma Ex-Pleiomorphic Adenoma of the Parotid Gland in a Single Tertiary Center.
Medicina (Kaunas)
December 2024
ENT Department, Carol Davila University of Medicine and Pharmacy, 050751 Bucharest, Romania.
: Carcinoma ex-pleiomorphic adenoma (CXPA) is a carcinoma derived from a primary or recurrent pleiomorphic adenoma. Microscopically, non-invasive CXPA (intracapsular and carcinoma in situ), minimally invasive CXPA (extracapsular invasion less than 1.5 mm), and invasive CXPA (extracapsular invasion more than 1.
View Article and Find Full Text PDF[Research progress in diagnosis and treatment of salivary gland tumors].
Beijing Da Xue Xue Bao Yi Xue Ban
February 2025
Department of Oral & Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
Salivary gland tumor is one of the most common tumors in oral and maxillofacial regions. The diagnosis and treatment of salivary gland tumors had been a clinical characteristic project in Peking University School and Hospital of Stomatology since long time ago. Here we introduced the research progress in diagnosis and treatment of salivary gland tumors during the past 10 years.
View Article and Find Full Text PDFLate-onset distant metastasis in parotid gland myoepithelial carcinoma.
BMJ Case Rep
January 2025
Department of Maxillofacial Surgery, Dubrava University Hospital, Zagreb, Croatia
Myoepithelial carcinoma (MC) is a rare salivary gland malignancy that usually affects people over the age of 50. The incidence is similar in both men and women. MC might develop de novo or within a pre-existing benign myoepithelioma or pleomorphic adenoma.
View Article and Find Full Text PDF[Analysis of clinical features of nasal pleomorphic adenoma].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
January 2025
Department of Otorhinolaryngology Head and Neck Surgery, Nasal Skull Base Surgery, the Affiliated Hospital of Qingdao University, Qingdao266000, China.
To analyze the clinical features of nasal pleomorphic adenoma and to share clinical insights into its diagnosis and treatment. This was a case series study. Clinical data of 12 patients with nasal pleomorphic adenoma, confirmed by histopathology, admitted to the Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Qingdao University from 2014 to 2023, were retrospectively analyzed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!