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Silent Inflammation: A Case of Blurry Vision Raising Diagnostic Challenges in an Elderly Patient.
Cureus
November 2024
Department of Medicine, Division of Rheumatology, Allergy and Immunology, Stony Brook University Hospital, Stony Brook, USA.
Giant cell arteritis (GCA) is a large vessel vasculitis with cranial and extracranial vessel involvement. Clinicians suspect GCA when a patient exhibits symptoms or exam findings of temporal headache with sudden vision loss, jaw or tongue claudication, scalp tenderness, abnormal temporal artery exam, and diagnostic findings, including elevated inflammatory markers. We present a case, which highlights that, despite established diagnostic measures, challenges persist.
View Article and Find Full Text PDFFrench protocol for the diagnosis and management of giant cell arteritis.
Rev Med Interne
January 2025
Department of Internal Medicine and Clinical Immunology, Referral Centre for Rare Systemic Autoimmune and Autoinflammatory Diseases (MAIS), Dijon Bourgogne University Hospital, Dijon, France; Inserm, EFS BFC, UMR 1098, RIGHT Graft-Host-Tumour Interactions/Cellular and Genetic Engineering, Bourgogne Franche-Comté University, Dijon, France. Electronic address:
Article Synopsis
- Giant cell arteritis (GCA) primarily affects women over 50, causing symptoms like headaches and jaw pain, and can lead to severe complications like vision loss due to eye involvement.
- Diagnosis relies on advanced imaging techniques such as FDG-PET and CT scans, while the temporal artery biopsy is considered the gold standard.
- Urgent treatment with high doses of corticosteroids is critical to prevent vision loss, and long-term management is necessary to monitor for recurrence and potential cardiovascular issues.
New onset of giant cell arteritis with ischaemic optic neuropathy following the seventh dose of COVID-19 mRNA vaccination: A case report and literature review.
Mod Rheumatol Case Rep
January 2025
Department of Ophthalmology, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan.
Article Synopsis
- - COVID-19 vaccines are effective at reducing disease severity, but some individuals may develop systemic rheumatic diseases post-vaccination, including giant cell arteritis (GCA).
- - A case study highlights a 73-year-old woman who experienced symptoms like headache and jaw pain shortly after her seventh COVID-19 mRNA vaccine dose, eventually leading to vision problems due to ischemic optic neuropathy.
- - The patient was diagnosed with GCA and received treatment, responding mildly to high-dose glucocorticoids and tocilizumab, which emphasizes the importance of monitoring such cases following vaccination.
Giant cell temporal arteritis: a clinicopathological study with emphasis on unnecessary biopsy.
Front Ophthalmol (Lausanne)
December 2023
Pathology and Laboratory Medicine Department, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
Introduction: Temporal artery (TA) biopsy is commonly used for the diagnosis of giant cell arteritis (GCA). However, a positive biopsy is no longer mandatory for diagnosis. This study aims to correlate the histopathological findings of TA biopsies in suspected cases of GCA to the clinical presentation in an ophthalmic tertiary eye care center to draw useful conclusions and advocate the possible implementation of guidelines for TA biopsy.
View Article and Find Full Text PDFFocal Neurotoxicity Associated With Topical 5-Fluorouracil.
Cureus
February 2024
Dermatology, Elkhorn Dermatology, Georgetown, USA.
Topical 5-Fluorouracil (5-FU) is an antineoplastic chemotherapy drug used to treat precancerous and cancerous skin growths, such as actinic keratoses (AKs), squamous cell carcinoma in situ, and superficial basal cell carcinoma. The topical agent may rarely cause neurotoxic adverse effects. Multiple cases of systemic 5-FU and capecitabine chemotherapy-induced neuropathies have been reported.
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