Several studies have examined the impacts of water, sanitation, hygiene, and general housing conditions on childhood health in developing countries. However, up-to-date knowledge and change pattern in common childhood illness prevalence over time are scarce in Nigeria. To contribute toward meeting the Sustainable Development Goals three and six, we used pooled data ( = 94,053) from the Nigeria Demographic Health Surveys from 2008 to 2018 to examine the trend and determinants of four childhood illnesses: diarrhea, fever, cough, and respiratory infection. Multivariate logistic regression was used to estimate the determinants of the four health outcomes. Our results indicate that between 2008 and 2018, the prevalence of childhood diarrhea, cough, and fever slowly declined. However, there was a drastic decline in childhood-related respiratory illness. Housing conditions, sanitation facilities, and water sources were significantly associated with childhood illness based on the logistic regression analysis. Based on our findings, we recommend general improvement in housing conditions that can eradicate childhood cough, fever, and respiratory infections.

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