Objective: To investigate an intensive asynchronous computer-based treatment delivered remotely with clinician oversight to people with aphasia.
Design: Single-blind, randomized placebo-controlled trial.
Setting: Free-standing urban rehabilitation hospital.
Participants: Adults with aphasia (at least six months post-onset).
Interventions: Experimental treatment was Web ORLA (Oral Reading for Language in Aphasia) which provides repeated choral and independent reading aloud of sentences with a virtual therapist. was a commercially available computer game. Participants were instructed to practice 90 minutes/day, six days/week for six weeks.
Main Measures: Change in Language Quotient of the Western Aphasia Battery-Revised from pre-treatment to post-treatment and pre-treatment to six weeks following the end of treatment.
Results: 32 participants (19 Web ORLA, 13 Control) completed the intervention and post-treatment assessment; 27 participants (16 Web ORLA, 11 Control) completed the follow-up assessment six weeks after treatment had ended. Web ORLA treatment resulted in significant improvements in language performance from pre-treatment to immediately post-treatment ( = 2.96; SD = 4.32; < 0.01; ES = 0.68) and from pre-treatment to six weeks following the end of treatment ( = 4.53; SD = 3.16; < 0.001; ES = 1.43). There was no significant difference in the gain from pre-treatment to post-treatment for the Web ORLA versus Control groups. However, the Web ORLA group showed significantly greater gains at the six-week follow-up than the control group ( = 2.70; SD = 1.01; = 0.013; ES = 1.92).
Conclusion: Results provide evidence for improved language outcomes following intensive, web-based delivery of ORLA to individuals with chronic aphasia. Findings underscore the value of combining clinician oversight with the flexibility of asynchronous practice.
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http://dx.doi.org/10.1177/0269215520988475 | DOI Listing |
BMJ Open
August 2023
Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Objective: To investigate the relationship between burn-out and spiritual health among medical doctors.
Design: Systematic literature review and narrative synthesis of cross-sectional studies.
Setting: Any setting, worldwide.
Clin Rehabil
July 2021
Institute of Cognitive Science, University of Colorado Boulder, Boulder, CO, USA.
Objective: To investigate an intensive asynchronous computer-based treatment delivered remotely with clinician oversight to people with aphasia.
Design: Single-blind, randomized placebo-controlled trial.
Setting: Free-standing urban rehabilitation hospital.
Mediterr J Rheumatol
June 2020
Department of Clinical Speech and Language Studies, Trinity College Dublin, Ireland.
Objective: Individuals presenting with rheumatoid arthritis (RA) frequently experience temporomandibular disorders (TMDs), which can result in limited ranges of mandibular motion, pain and fatigue on jaw function, and impaired mastication. As such, individuals with RA-related TMDs may consume a texture-modified diet in order to reduce the exacerbation of jaw pain and dysfunction, and to increase the ease of oral intake. These softer food options may not contain the recommended nutrients, vitamins, and minerals, and therefore, may not be nutritionally optimal.
View Article and Find Full Text PDFAim: This scoping review will gather existing evidence on specific interventions at presentation and discharge which aim to standardize care and/or reduce unnecessary admissions and/or readmissions to hospital for patients presenting with acute exacerbation of chronic obstructive pulmonary (airways) disease.
Design: Scoping review of relevant literature from January 2000-March 2019.
Methods: Database searches for primary evidence in peer-reviewed journals will be conducted electronically using Web of Science, EMBASE (Elsevier) and PUBMED.
Cochrane Database Syst Rev
November 2019
University Hospital Southampton NHS Foundation Trust, Department of Clinical Biochemistry, 17 Tremona Road, Southampton, UK, SO16 6YD.
Background: Wilson's disease, first described by Samuel Wilson in 1912, is an autosomal recessive metabolic disorder resulting from mutations in the ATP7B gene. The disease develops as a consequence of copper accumulating in affected tissues. There is no gold standard for the diagnosis of Wilson's disease, which is often delayed due to the non-specific clinical features and the need for a combination of clinical and laboratory tests for diagnosis.
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