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Corticosteroid-Resistant Sarcoid Choroidal Granuloma Presenting With Optic Disc Edema.
J Neuroophthalmol
March 2022
Department of Ophthalmology and Visual Neurosciences (KRA, MSL), University of Minnesota, Minneapolis, Minnesota; and Department of Ophthalmology (KRA), Veterans Affairs Health Care System, Minneapolis, Minnesota.
A Remarkable Response of Granulomatous Hypophysitis to Infliximab in a Patient With a Background of Crohn's Disease-A Case Report.
Front Endocrinol (Lausanne)
May 2021
Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, United States.
Hypophysitis is primary or idiopathic or secondary to another disease process. The histologic subtypes of hypophysitis are lymphocytic, granulomatous, xanthomatous, xanthogranulomatous, or IgG4-related. Granulomatous hypophysitis is the second most common form and is characterized by multinucleated giant cells with granulomas and histiocytes.
View Article and Find Full Text PDFCorticosteroid-resistant bulbar neurosarcoidosis responsive to intravenous immunoglobulin.
Pract Neurol
August 2015
Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA.
We report an intriguing case of corticosteroid-resistant bulbar neurosarcoidosis responding to intravenous immunoglobulin. A 37-year-old man presented with dysphagia to solids and liquids, dysphonia, fatigue and 50 lb weight loss over 2 months. We suspected sarcoidosis, based on an elevated serum angiotensin-converting enzyme concentration and hilar lymphadenopathy on chest imaging; we subsequently confirmed this after transbronchial biopsy found non-caseating granulomas.
View Article and Find Full Text PDFMusculoskeletal involvement in sarcoidosis.
J Bras Pneumol
November 2014
University Hospital, Fez, Morocco.
Article Synopsis
- - Sarcoidosis is an inflammatory disorder affecting various systems, mostly the lungs, and can lead to unique musculoskeletal issues including joint pain, arthritis, and specific syndromes like Löfgren's.
- - Diagnosis is mainly through imaging techniques (like X-rays and MRIs) but requires biopsy for confirmation; muscle involvement is rare and usually not symptomatic.
- - Treatment typically involves nonsteroidal anti-inflammatory drugs or corticosteroids, and in resistant cases, immunosuppressive therapies such as methotrexate or anti-TNF-α may be used.
Treatment of corticosteroid-resistant neurosarcoidosis with a short-course cyclophosphamide regimen.
Chest
November 2003
Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina Charleston, SC 29425, USA.
Article Synopsis
- A study explored the effectiveness of a short-course cyclophosphamide treatment for patients with neurosarcoidosis who either did not respond to or could not tolerate corticosteroids due to side effects.
- Seven patients were treated, with a mean therapy duration of 5.4 months, where four showed symptomatic improvement and all showed objective changes in MRI or cerebrospinal fluid results.
- The average corticosteroid dosage decreased significantly from 42 mg/day to 18 mg/day post-treatment, indicating cyclophosphamide may help manage symptoms while minimizing steroid use.
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