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| http://dx.doi.org/10.1097/CM9.0000000000001363 | DOI Listing |
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Liraglutide and GLP-1(9-37) alleviated hepatic ischemia-reperfusion injury by inhibiting ferroptosis via GSK3β/Nrf2 pathway and SMAD159/Hepcidin/FTH pathway.
Redox Biol
December 2024
Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China. Electronic address:
Ferroptosis plays a pivotal role in the pathogenesis of ischemia-reperfusion injury (IRI). Liraglutide, as a GLP-1 receptor (GLP-1R) agonist, has exhibited extensive biological effects beyond its hypoglycemic action. Recent studies have shed light on the regulatory influence of Liraglutide on ferroptosis, yet the precise underlying mechanism remains elusive.
View Article and Find Full Text PDFAcute GLP-1 Agonism Induces Arrhythmogenic Electrical Activity in Aged Mice Heart Through Impaired Cellular Na+ and Ca2+ Handlings: The Role of CK2 Hyperphosphorylation.
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December 2024
Department of Biophysics, Faculty of Medicine, Lokman Hekim University, Ankara, Türkiye.
Background: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are known for their benefits in conditions like cardiovascular diseases in type 2 diabetes and obesity. They also show promise for aging-related conditions with minimal side effects. However, their impact on cardiovascular risk is still debated.
View Article and Find Full Text PDFNew horizon of the combined BCG vaccine with probiotic and liraglutide in augmenting beta cell survival suppression of TXNIP/NLRP3 pyroptosis signaling in Streptozocin-Induced diabetes mellitestype-1 in rats.
Heliyon
October 2024
Department of Medical Pharmacology, Faculty of Medicine, Cairo University, El- Manial, Cairo 11562, Egypt.
Background: An ideal anti-diabetic type-1 pharmacotherapy should combine abrogation of beta cell pyroptosis with enhancement of beta cell mass.
Objectives: The study investigated the potential synergism from combining the Bacillus Calmette-Guerin (BCG) vaccine with liraglutide (LIR) and probiotics in mitigating Streptozocin (STZ)-induced Type1diabetes mellitus in albino rats suppression of TXNIP/NLRP3 signaling. Induction of diabetes was performed by two I.
Molecular connectomics reveals a glucagon-like peptide 1-sensitive neural circuit for satiety.
Nat Metab
December 2024
Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA.
Liraglutide and other glucagon-like peptide 1 receptor agonists (GLP-1RAs) are effective weight loss drugs, but how they suppress appetite remains unclear. One potential mechanism is by activating neurons that inhibit the hunger-promoting Agouti-related peptide (AgRP) neurons of the arcuate hypothalamus (Arc). To identify these afferents, we developed a method combining rabies-based connectomics with single-nucleus transcriptomics.
View Article and Find Full Text PDFRecent Advances and Therapeutic Benefits of Glucagon-Like Peptide-1 (GLP-1) Agonists in the Management of Type 2 Diabetes and Associated Metabolic Disorders.
Cureus
October 2024
Internal Medicine, Danylo Halytsky Lviv National Medical University, Lviv, UKR.
Article Synopsis
- * These medications also promote significant weight loss and offer benefits for cardiovascular and renal health, along with potential protection against neurodegenerative diseases like Alzheimer's and Parkinson's.
- * The review emphasizes the need for ongoing research to maximize the clinical applications of GLP-1 agonists and explore new treatment possibilities in various health conditions, including Obstructive Sleep Apnea and stroke risk reduction.
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