AI Article Synopsis
- The study focused on comparing how effective and safe initial antiretroviral therapy (ART) was for premenopausal versus postmenopausal women with HIV aged 45-60.
- Researchers used multivariable regression models to analyze viral suppression, changes in CD4 T-cell counts, and time to treatment changes over 48 and 96 weeks.
- Results showed no significant differences in outcomes between the two groups, indicating that ART was similarly effective and safe for both pre- and postmenopausal women.
Article Abstract
Background: To compare effectiveness and safety of initial antiretroviral therapy (ART) among premenopausal and postmenopausal women living with HIV aged 45-60 years from the cohort of the Spanish HIV/AIDS Research Network (CoRIS) who initiated ART between 2004 and 2015.
Methods: Multivariable regression models were used to compare post- versus premenopausal women regarding viral suppression (≤50 copies/ml), change in CD4 T-cell count and time to treatment change (TC) at 48 and 96 weeks after ART initiation.
Results: Among 230 women, 154 (67%) were premenopausal at ART initiation. The most frequent initial regimen was tenofovir disoproxil fumarate/emtricitabine/efavirenz prescribed in 49 (32%) premenopausal and 22 (29%) postmenopausal women. The proportion of TC was 35.7% and 30.3% at 48 weeks and 51.3% and 47.4% at 96 weeks, for pre- and postmenopausal women, respectively. There were no significant differences in CD4 T-cell count changes from ART initiation, viral load suppression, time to TC or reason for TC between both groups. The main reason for TC was occurrence of an adverse event, followed by simplification, in both groups.
Conclusions: ART effectiveness and safety did not differ significantly between pre- and postmenopausal women.
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| http://dx.doi.org/10.3851/IMP3380 | DOI Listing |
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