AI Article Synopsis
- Lombardy, Italy had the highest SARS-CoV-2 cases globally from February to April 2020, leading to an analysis of 346 viral genomes.
- Researchers identified seven distinct viral lineages in the region, with some likely emerging locally in Italy.
- The study found evidence of community transmission occurring prior to the first official COVID-19 case report in Lombardy, along with specific genetic mutations in the virus sequences.
Article Abstract
From February to April 2020, Lombardy (Italy) reported the highest numbers of SARS-CoV-2 cases worldwide. By analyzing 346 whole SARS-CoV-2 genomes, we demonstrate the presence of seven viral lineages in Lombardy, frequently sustained by local transmission chains and at least two likely to have originated in Italy. Six single nucleotide polymorphisms (five of them non-synonymous) characterized the SARS-CoV-2 sequences, none of them affecting N-glycosylation sites. The seven lineages, and the presence of local transmission clusters within three of them, revealed that sustained community transmission was underway before the first COVID-19 case had been detected in Lombardy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815831 | PMC |
| http://dx.doi.org/10.1038/s41467-020-20688-x | DOI Listing |
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