Background: Colorectal cancer (CRC) is the third most common cancer worldwide, characterized by a multifactorial etiology including genetics, lifestyle, and environmental factors including microbiota composition. To address the role of microbial modulation in CRC, we used our recently established mouse model (the Winnie-APC) combining inflammation and genetics.
Methods: Gut microbiota profiling was performed on 8-week-old Winnie-APC mice and their littermates by 16S rDNA gene amplicon sequencing. Moreover, to study the impact of dysbiosis induced by the mother's genetics in ACF development, the large intestines of APC mice born from wild type mice were investigated by histological analysis at 8 weeks.
Results: ACF development in 8-week-old Winnie-APC mice was triggered by dysbiosis. Specifically, the onset of ACF in genetically predisposed mice may result from dysbiotic signatures in the gastrointestinal tract of the breeders. Additionally, fecal transplant from Winnie donors to APC hosts leads to an increased rate of ACF development.
Conclusions: The characterization of microbiota profiling supporting CRC development in genetically predisposed mice could help to design therapeutic strategies to prevent dysbiosis. The application of these strategies in mothers during pregnancy and lactation could also reduce the CRC risk in the offspring.
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http://dx.doi.org/10.3390/cancers13020283 | DOI Listing |
BMC Public Health
December 2024
Department of Global Health and Social Medicine, King's College London, London, WC2B 4BG, UK.
Background: Fasting and time-restricted eating (TRE) are popular practices that have health benefits, but may also carry a risk of harm. Little is known about the impact of TRE during pregnancy on the long-term health of offspring beyond the immediate post-natal period.
Methods: We conducted a systematic review and narrative synthesis of research on the health impact of time-restricted eating (TRE) during pregnancy and its potential long-term effects on offspring.
BMC Glob Public Health
March 2024
Department of Global Public Health, WHO Collaborating Centre On TB and Social Medicine, Karolinska Institutet, Stockholm, Sweden.
Background: The psychosocial consequences of tuberculosis (TB) are key barriers to ending TB globally. We evaluated and compared stigma, depression, and quality of life (QoL) among people with TB diagnosed through active (ACF) and passive (PCF) case-finding in Nepal.
Methods: We prospectively recruited adults with TB diagnosed through ACF and PCF in four districts of Nepal between August 2018 and April 2019.
Heliyon
March 2024
Department of Fisheries Biology and Genetics, Faculty of Fisheries, Bangladesh Agricultural University, Mymensingh, Bangladesh.
Tilapia farming has expanded rapidly in Bangladesh over the years thanks to a suitable climate for aquaculture and a consistently increasing demand for the fish rich in vitamins and minerals. A clear picture regarding the future trend of tilapia production in Bangladesh is still not available, however. The purpose of this study was to estimate parameters that fit into the Autoregressive Integrated Moving Average (ARIMA) model for forecasting tilapia production in Bangladesh.
View Article and Find Full Text PDFEur J Appl Physiol
December 2024
Department of Biomedical Sciences, University of Padua, Via Marzolo, 3, 35131, Padua, Italy.
Entropy (Basel)
October 2024
School of Information and Navigation, Air Force Engineering University, Xi'an 710077, China.
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