The stopping power of liquid water was measured for carbon ions with energies in the Bragg peak region using the inverted Doppler shift attenuation method. Among the semiempirical data, the results of this work agree best with the data recommended in the Errata and Addendum of ICRU Report No. 73, which is based on an I value of 78 eV for water. The agreement was worse when the present results were compared to the newer recommendation of the ICRU published in ICRU Report No. 90. The srim code seems to slightly overestimate the stopping power of water for carbon ions above 3 MeV. A semiexperimental stopping power of water for α particles was derived from the present results using the theoretical ratio between the stopping powers of water for carbon ions and α particles computed by means of the casp code. These values agree well with the experimental data for α particles within the uncertainties.
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http://dx.doi.org/10.1103/PhysRevE.102.062418 | DOI Listing |
Nat Commun
January 2025
Vertex Pharmaceuticals Incorporated, Boston, MA, USA.
Chronic kidney disease affects ~10% of people worldwide and there are no disease modifying therapeutics that address the underlying cause of any form of kidney disease. Genome wide association studies have identified the G1 and G2 variants in the apolipoprotein L1 (APOL1) gene as major contributors to a subtype of proteinuric kidney disease now referred to as APOL1-mediated kidney disease (AMKD). We hypothesized that inhibition of APOL1 could have therapeutic potential for this genetically-defined form of kidney disease.
View Article and Find Full Text PDFClin Trials
January 2025
Department of Biostatistics, University of Washington, Seattle, WA, USA.
Background: N-of-1 trials compare two or more treatment options for a single participant. These trials have been used to study options for chronic conditions such as arthritis and attention deficit hyperactivity disorder. In addition, they have been suggested as a means to study interventions in rare populations that may not be tractable to include in standard clinical trials, such as treatment options for HIV-positive patients in need of organ transplant.
View Article and Find Full Text PDFBiomed Eng Online
December 2024
Delta Tooling Co., LTD, 1-2-10, Yanoshinmachi, Aki-Ku, Hiroshima, 736-0084, Japan.
Background: Spinal cord injury (SCI) often leads to the loss of urinary sensation, making urination difficult. In a previous experiment involving six healthy participants, we measured heartbeat-induced acoustic pulse waves (HAPWs) at the mid-back, calculated time-series power spectra of heart rate gradients at three ultralow/very low frequencies, distinguished and formulated waveform characteristics (one characteristic for each power spectrum, nearly uniform across participants) at times of increased urine in the bladder and heightened urges to urinate, and developed an algorithm with five of these power spectra to identify when urination is needed by extracting the waveform portion (continuous timepoints) where all of the characteristics were consistent with the formulated characteristics. The objective of this study was to verify the validity of the algorithm fed with data from measured HAPW of participants with SCI and to adapt the algorithm for these individuals.
View Article and Find Full Text PDFSaf Health Work
December 2024
College of Safety Science and Engineering, Xi'an University of Science and Technology, Xi'an, Shaanxi, China.
Background: In the Chinese coal industry, widespread blame avoidance behavior (BAB) greatly impacts coal mine accidents. Therefore, it is necessary to stop the BAB of coal mine managers and raise the management level of coal mine enterprises for the safe development of Chinese coal industry.
Methods: Based on the semi-structured interviews and questionnaire surveys (20 middle-level managers in coal mines), this paper used the Grounded Theory and Nvivo Software qualitative research methodology to open, spindle, and selectively encode the interview data.
Med Phys
December 2024
Medical Physics Department, Azienda Provinciale per i Servizi Sanitari (APSS), Trento, Italy.
Background: In Proton Therapy, the presence of implants along the beam path is known to potentially affect the dose distribution. The way such implants are managed in the planning process can vary in the different treatment planning systems (TPSs) and different centers. A specific validation procedure should be accomplished to verify the accuracy of TPS computation in these conditions and accept the applied process before treating patients.
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