AI Article Synopsis
- The study focused on the changes in polypropylene (PP) mesh used in midurethral slings for treating stress urinary incontinence, analyzing explants removed from patients dealing with pain or obstruction.
- Ten PP explants were examined using advanced techniques like scanning electron microscopy and spectroscopy to assess their degradation over time, while one pristine control sample was used for comparison.
- Results indicated significant bioerosion and increased oxygen content on the explants, suggesting that oxidative degradation occurred within the body over time.
Article Abstract
This study was performed to investigate the changes over time in polypropylene (PP) mesh explants from women with stress urinary incontinence originally treated with a midurethral PP sling. Following Institutional Review Board (IRB) approval, 10 PP explants removed for pain or obstructive symptoms between January and June 2016 were analyzed through various techniques to determine the degradation of the material in vivo. Exclusion criteria were exposed or infected mesh sling or sling in place for less than six months. One pristine control was studied for comparison. The explant samples were analyzed with scanning electron microscopy to visualize the surface defects as well as infrared spectroscopy and energy dispersive X-ray spectroscopy to determine if the degradation was oxidative in nature. The results show qualitative and quantitative bioerosion over the surface of the explant samples and an increase in the content of oxygen pointing toward oxidative degradation occurring in vivo.
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| http://dx.doi.org/10.1021/acsbiomaterials.7b00614 | DOI Listing |
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